Search for dissertations about: "carbohydrate NMR"

Showing result 1 - 5 of 52 swedish dissertations containing the words carbohydrate NMR.

2. 1. Deciphering Carbohydrate Structure : From NMR Chemical Shifts to Conformational Analysis

   Author : Kevin M. Dorst; Göran Widmalm; Martina Delbianco; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR chemical shift prediction; Structural elucidation; Conformational studies; NMR spectroscopy; MD simulations; Organic Chemistry; organisk kemi;

   Abstract : Carbohydrates are ubiquitous in nature and exhibit a multitude of roles. Besides nucleic and amino acids, they can be regarded as the third alphabet of life. They are used as energy source to fuel the cells, as structural building blocks and play a key role in cellular recognition processes. READ MORE

4. 2. Carbohydrate-Functionalized Nanomaterials : Synthesis, Characterization and Biorecognition Studies

   Author : Na Kong; Mingdi Yan; Joseph J. Barchi Jr; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbohydrate; glyconanomaterials; perfluorophenyl azide PFPA ; CuAAC; AAAC; coupling chemistry; 19 F q NMR; lectin; carbon nanomaterials; microwave irradiation; Kemi; Chemistry; Bioteknologi; Biotechnology;

   Abstract : This thesis focuses on the development of carbohydrate coupling chemistry on nanomaterials and their biological activity studies. It is divided into two parts:In part one, two carbohydrate immobilization approaches, based on perfluorophenyl azide (PFPA)-functionalized silica nanoparticles (SNPs), are presented, where the binding affinity of the glyconanoparticles was evaluated through carbohydrate-lectin interaction. READ MORE

5. 3. The sweet side of molecular structure : NMR spectroscopic studies of glycans and their interactions with proteins

   Author : Christoffer Hamark; Göran Widmalm; Mario Schubert; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioorganic chemistry; glycans; ligand-based NMR; molecular simulations; protein-carbohydrate interactions; lectins; carbohydrate conformations; 77Se NMR; structure-reactivity relationships; super-armed donors; organisk kemi; Organic Chemistry;

   Abstract : In this thesis, within the topic of bioorganic chemistry, the molecular structure of carbohydrates has been studied. Carbohydrates, or glycans, are ubiquitous biomolecules exhibiting a wide range of biological roles. READ MORE

6. 4. Structure, dynamics and reactivity of carbohydrates : NMR spectroscopic studies

   Author : Jerk Rönnols; Göran Widmalm; Mikael Bols; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrates; Conformation; NMR spectroscopy; Hydrogen bond; organisk kemi; Organic Chemistry;

   Abstract : The main focus of this thesis is on the ring conformations of carbohydrate molecules; how the conformational equilibria and the rates of the associated interconversions are affected by the molecular constitution and their surroundings.The conformational equilibria of a group of amine linked pseudodisaccharides, designed as potential glycosidase inhibitors, comprising α-D-altrosides are described in Chapter 3. READ MORE

7. 5. Molecular recognition and dynamics in proteins studied by NMR

   Author : Johan Wallerstein; Biofysikalisk kemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity; Chemical exchange; Conformational entropy; Entropy; Galectin-3; Isothermal Titration Calorimetry; ITC; Model-free formalism; Molecular recognition; Nuclear Magnetic Resonance; NMR; PGB1; Protein dynamics; Protein–ligand interactions; Proton-transfer reactions; Spin relaxation; Viscosity;

   Abstract : Knowledge of dynamics in protein is very important in the description of protein function and molecular recognition. The thesis investigates protein dynamics on time-scales from milli- to sub-nanosecond, with focus on the latter, using NMR spin relaxation experiments on two proteins, the 138-residue carbohydrate recognition domain of galectin-3 (Gal3C) and the 56-residue B1 domain of bacterial protein G (PGB1). READ MORE