Search for dissertations about: "carbon-11"
Showing result 1 - 5 of 21 swedish dissertations containing the word carbon-11.
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1. Development of Palladium-Promoted 11C/12C-Carbonylations and Radiosynthesis of Amyloid PET Ligands
Abstract : In the first part of this thesis, palladium(0)-catalyzed and -mediated carbonylations are discussed. Paper I describes a new method for the safe, efficient use of a solid carbon monoxide source in the synthesis of primary and secondary benzamides. READ MORE
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2. Visualization of Peripheral Pain Generating Processes and Inflammation in Musculoskeletal Tissue using [11C]-D-deprenyl PET
Abstract : An objective visualization and quantification of pain-generating processes in the periphery would alter pain diagnosis and represent an important paradigm shift in pain research. Positron emission tomography (PET) radioligand [11C]-D-deprenyl has shown an elevated uptake in painful inflammatory arthritis and whiplash-associated disorder. READ MORE
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3. Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods
Abstract : Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. READ MORE
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4. Production of photoneutron beams and radionuclides by photonuclear reactions using a 50 MeV racetrack microtron
Abstract : The feasibility of using electrons accelerated by a 50 MeV racetrack microtron to generate a mixed beam of neutrons and photons for radiation therapy and for production of radionuclides has been investigated.To develop target systems for these purposes the angular distribution and yield of bremsstrahlung from different targets have been studied theoretically. READ MORE
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5. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter
Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE