Search for dissertations about: "carbonylation"

Showing result 16 - 20 of 39 swedish dissertations containing the word carbonylation.

  2. 16. Design and Synthesis of Inhibitors Targeting the Hepatitis C Virus NS3 Protease : Focus on C-Terminal Acyl Sulfonamides

    Author : Robert Rönn; Anders Hallberg; Anja Sandström; Federico Corelli; Uppsala universitet; []
    Keywords : Pharmaceutical chemistry; hepatitis C virus; HCV; NS3 protease inhibitor; acyl sulfonamide; bioisostere; palladium; carbonylation; microwave; molybdenum hexacarbonyl; Farmaceutisk kemi;

    Abstract : Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). READ MORE

  4. 17. Development of Substance P 1–7 Related Peptides and Peptidomimetics : Targeting Neuropathic Pain

    Author : Anna Skogh; Anja Sandström; Christian Sköld; Rebecca Fransson; Philip Thompson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Substance P 1–7; Peptidomimetics; Solid-phase Peptide Synthesis SPPS ; Palladium catalysis; Carbonylation; Imidazole; Bioisostere; Neuropathic pain; Allodynia; Structure-activity relationships; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The neuropeptide substance P 1–7 (SP1–7, H-Arg1-Pro2-Lys3-Pro4-Gln5-Gln6-Phe7-OH) and its amidated analogue SP1–7 amide, have displayed intriguing effects in experimental models for neuropathic pain acting on a specific, yet unknown SP1–7 target. The aim of this thesis was to design and synthesise SP1–7 related peptides and peptidomimetics, to be used as research tools to study the SP1–7 system, and to serve as drug leads in the neuropathic pain area. READ MORE

  5. 18. Methodological advancements in microfluidic and carbonylation PET radiochemistry

    Author : Kenneth Dahl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Along with the progress of PET as a powerful imaging tool in medicine, there has been increasing demand for new labeling methods. The main aim of this PhD dissertation was to develop novel labeling methodologies using the positron emitter carbon-11. READ MORE

  6. 19. [11C]Carbon Monoxide in Palladium- / Selenium-Promoted Carbonylation Reactions : Synthesis of 11C-Imides, Hydrazides, Amides, Carboxylic Acids, Carboxylic Esters, Carbothioates, Ketones and Carbamoyl Compounds

    Author : Farhad Karimi; Kalman Szabo; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : [11C]Carbon monoxide in low concentrations has been used in palladium- or seleniummediated carbonylation reactions such as the synthesis of 11C-imides, hydrazides, amides, carboxylic acids, esters, carbothioates, ketones and carbamoyl compounds.In these reactions aryl iodides have been used in most cases. READ MORE

  7. 20. Protein Damage Control during Embryonic Stem Cell Differentiation: Role of the Proteasome

    Author : Malin Hernebring; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Embryonic Stem Cells; Proteasome; Protein Carbonylation; Advanced Glycation End products; Cell Differentiation; Oxidative stress; Aging; RNAi;

    Abstract : During the lifespan of organisms ranging from yeast to humans, there is an accumulation of macromolecular damage. However, these organisms produce youthful progeny with low damage levels. This thesis focuses on how this is accomplished. READ MORE