Search for dissertations about: "carbonylation"

Showing result 6 - 10 of 34 swedish dissertations containing the word carbonylation.

  1. 6. Palladium(0)-Catalysed Carbonylative Multicomponent Reactions Synthesis of Heterocycles and the Application of Quinolinyl Pyrimidines as Enzyme Inhibitors

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Linda Åkerbladh; Mats Larhed; Luke Odell; Anders Karlén; Lise-Lotte Gundersen; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Carbonylation; Multicomponent reactions; Domino reactions; Heterocycles; 4-Quinolones; 2-Aminoquinazolinones; Benzoxazinones; N-Acylguanidines; Type II NADH dehydrogenase; NDH-2;

    Abstract : Palladium-catalysed carbonylative multicomponent reactions have proven useful for the synthesis of structurally diverse compounds. Carbon monoxide serves as an atom-efficient, one-carbon building block, which allows for further structural elaboration of the carbonyl compound. READ MORE

  2. 7. Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters

    University dissertation from Stockholm : KTH Royal Institute of Technology

    Author : Jakob Danielsson; Peter Somfai; Hans Adolfsson; Tobias Rein; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric induction; stereochemical models; Mukaiyama; polar Felkin-Anh; Cornforth-Evans; 1; 3-dipole; aziridine; cycloaddition; amino alcohol; carbonylation; Heck reaction; quaternary stereocenter;

    Abstract : This thesis deals with the development of new reaction methodology as well as stereochemical investigations.The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. READ MORE

  3. 8. Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Stefan Berlin; Lars Engman; Mario D. Bachi; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; radical; cyclization; carbonylation; melatonin; pyrrolidine; pyrrolidin-3-one; tetrahydrofuran-3-one; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Abstract : This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared via a PhSeCl-addition/HCl-elimination sequence. READ MORE

  4. 9. Multicomponent Reactions in 11C/12C Chemistry – Targeting the Angiotensin II Subtype 2 Receptor

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marc Stevens; Luke Odell; Mats Larhed; Gunnar Antoni; Sergio Estrada; Ola Åberg; Neil Vasdev; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; carbonylation; positron emission tomography; multicomponent reactions; AT2R; 3; 4-dihydroquinazolinone; sulfonyl azides; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Section 1 of this thesis contains an introduction to method development in organic synthesis, multicomponent reactions, sulfonyl azides, tracer development in 11C chemistry and the biological target.Section 2 describes the use of sulfonyl azides in carbonylative chemistry. Paper I covers development of a diazotransfer protocol. READ MORE

  5. 10. Discovery of Small Peptides and Peptidomimetics Targeting the Substance P 1-7 Binding Site Focus on Design, Synthesis, Structure-Activity Relationships and Drug-Like Properties

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Rebecca Fransson; Anja Sandström; John S Svendsen; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P 1-7; peptidomimetics; structure-activity relationship; drug-like properties; phenylalanine; imidazole; MAP aryl amides; carbonylation; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Biologically active peptides are important for many physiological functions in the human body and therefore serve as interesting starting points in drug discovery processes. In this work the neuropeptide substance P 1–7 (SP1–7, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH), which has been demonstrated to reduce neuropathic pain and attenuate opioid withdrawal symptoms in animal models, has been addressed in a medicinal chemistry program with the overall aim of transforming this bioactive peptide into more drug-like compounds. READ MORE