Search for dissertations about: "carboxypeptidase b"

Showing result 1 - 5 of 8 swedish dissertations containing the words carboxypeptidase b.

  2. 1. Acute pancreatitis. With special reference to the activation peptide from carboxypeptidase B (CAPAP) as a predictor of severity

    Author : Stefan Appelros; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; accuracy; exocrine dysfunction; radioimmunoassay; CAPAP; carboxypeptidase B; activation peptide; aetiology; prediction of severity; morbidity; mortality; severe acute pancreatitis; Incidence; acute pancreatitis; sensitivity; specificity; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : There is a wide range in the reported annual incidence of acute pancreatitis (AP). A minority of these patients develop a severe disease characterised by a high mortality and morbidity. In order to improve the outcome for patients with an attack of severe AP it is important to identify these patients early in the course of disease. READ MORE

  4. 2. Protease Activation and Inflammation in Acute Pancreatitis

    Author : Sara Regnér; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prediction of severity; CAPAP; proCAP; aCAP; Acute pancreatitis; MCP-1; Carboxypeptidase B; fibrinolysis;

    Abstract : Approximately 10—20 % of patients with acute pancreatitis (AP) develop a severe disease with high mortality and morbidity. Activation of pancreatic proteases, the inflammatory response and impaired pancreatic circulation are pathophysiological events that are important in order for the disease to develop. READ MORE

  5. 3. Enzyme selectivity as a tool in analytical chemistry

    Author : Anders Hamberg; Karl Hult; Harry Brumer; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; substrate specificity; competing substrates; enantiomeric excess analysis; library screening; ladder sequencing; carboxypeptidase Y; 2-pyridylmethylamine; MALDI; Candia antarctica lipase B; pig liver esterase; horse liver alcohol dehydrogenase; acylated cyanohydrins; Biochemistry; Biokemi;

    Abstract : Enzymes are useful tools as specific analytical reagents. Two different analysis methods were developed for use in the separate fields of protein science and organic synthesis. Both methods rely on the substrate specificity of enzymes. Enzyme catalysis and substrate specificity is described and put in context with each of the two developed methods. READ MORE

  6. 4. Trypsinogen and Its Activation in Acute Pancreatitis

    Author : Ulf Petersson; Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TAP; ERCP; carboxypeptidase B activation peptide; trypsinogen activation peptide; trypsinogen activation; Acute pancreatitis; trypsinogen; CAPAP; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Abstract : Pancreatic enzymes, neutrophils, free radicals and cytokines are involved in the pathophysiology of AP. Clarification of their interaction and time-course will improve our understanding of AP and provide a better basis for treatment. READ MORE

  7. 5. Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry

    Author : Anders Hamberg; Karl Hult; Dick Janssen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica lipase B; monoacylation of diols; kinetic resolution; thermodynamics in enzyme catalysis; enzyme engineering; Biochemistry; Biokemi;

    Abstract : The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. READ MORE