Search for dissertations about: "carcinogen"

Showing result 1 - 5 of 43 swedish dissertations containing the word carcinogen.

  2. 1. Exposure to xenobiotic chemicals disrupts metabolism, rhythmicity and cell proliferation in Drosophila melanogaster

    Author : Hao Cao; Helgi B. Schiöth; Michael J. Williams; Jan Larsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; xenobiotics; metabolism; insulin signalling; circadian rhythm; carcinogen; Biomedical Laboratory Science; Biomedicinsk laboratorievetenskap;

    Abstract : Most species are constantly exposed to xenobiotic chemicals through multiple routes. Among all categories of xenobiotics, phthalates and bisphenols are two of the most widely used plasticizers and can be found in polyvinyl chloride (PVC) materials, medical devices and even drinking water. READ MORE

  4. 2. Development of methods for determining aflatoxins in biological material

    Author : Anders Kussak; Rainer Stephany; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aflatoxins; Mycotoxins; Carcinogen; Airborne dust; Urine; Feed factories; Immunoaffinity extraction; Solid-phase extraction; Post-column derivatization; Electrospray; Mass spectrometry;

    Abstract : In this thesis, it is shown how aflatoxins can be determined in biological material. The thesis is a summary of five papers.Aflatoxins are carcinogenic mycotoxins produced by Aspergillus moulds. Methods were developed for the determination of aflatoxins in samples of airborne dust and human urine collected at feed factories. READ MORE

  5. 3. Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death

    Author : Martin Vondracek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The oral mucosa is globally a common site for cancer development. Primary risk factors include tobacco smoking and alcohol consumption whereas the contribution from usage of smokeless tobacco remains debated. READ MORE

  6. 4. A novel technology for studying the disposition of drugs and toxicants in the lung : short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols

    Author : Pär Ewing; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aerosol; inhalation; rat; lung; absorption; drugs; carcinogen; particles;

    Abstract : The disposition of solutes following the deposition of inhaled substances in the lung is a complex process that proceeds along parallel paths; passive diffusion of solutes through the air/blood barrier and local metabolism followed by blood-borne clearance to the circulation. Using the isolated and perfused lung (IPL) the pulmonary disposition of inhaled particles can be studied in great detail without interference from distal organs and systemic exposure. READ MORE

  7. 5. Binding of benzo(a)pyrene metabolites and derivatives to DNA : characterization using optical spectroscopy techniques

    Author : Ola Undeman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : DNA with covalently bound benzo(a)pyrene (BP) derivatives was studied with fluorescence spectroscopy, fluorescence decay measurements, fluorescence quenching measurements, light absorption and linear dichroism of flow oriented samples. The modified DNA was prepared in three different ways: (1) by incubating calf thymus DNA with rat liver micromomes, necessary cofactors and benzo(a)pyrene or derivatives of benzo(a)pyrene, (2) by isolating DNA. READ MORE