Search for dissertations about: "carcinoma 2010"

Showing result 1 - 5 of 42 swedish dissertations containing the words carcinoma 2010.

  2. 1. Localised and Metastatic Renal Cell Carcinoma. Aspects of Treatment

    Author : David Lyrdal; Göteborgs universitet; []
    Keywords : renal cell carcinoma; nephron-sparing surgery; 18F -2-flouro-2-deoxyglucose; positron emission tomography; metastatic renal cell carcinoma; peg-interferon alfa-2b; radiofrequency; ablation; percutaneous; ultrasound;

    Abstract : Localised and Metastatic Renal Cell Carcinoma. Aspects of Treatment. Aims: Paper I To assess the long-term results in patients operated with NSS in situ for RCC, with special reference to their dependence on tumour grade and stage. READ MORE

  4. 2. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Author : Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Abstract : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. READ MORE

  5. 3. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

    Author : Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

    Abstract : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. READ MORE

  6. 4. Predictive and prognostic biomarkers in oral tongue squamous cell carcinoma

    Author : Michael Ryott; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oral tongue squamous cell carcinoma (OTSCC) is an aggressive disease frequently associated with poor prognosis due to the high risk of regional failure and mortality rates have been practically unchanged in Sweden the last fifty years, despite advancements in both diagnostics and treatment. Today we lack means to assess the biological aggressiveness of each individual tumor which varies largely. READ MORE

  7. 5. Predictive markers : for treatment sensitivity in head and neck squamous cell carcinoma

    Author : Lovisa Farnebo; Karin Roberg; Ann-Charlotte Johansson; Lena Norberg-Spaak; Antti Mäkitie; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Head and neck cancer is the sixth most common cancer world wide. In Sweden approximately 850 new cases are diagnosed each year, and two thirds are men. The past decades of improved treatment strategies have unfortunately not significantly improved the five-year survival rates for this group of patients. READ MORE