Search for dissertations about: "carcinoma cell line"

Showing result 1 - 5 of 106 swedish dissertations containing the words carcinoma cell line.

  2. 1. Signalling pathways in renal cell carcinoma with a focus on telomerase regulation

    Author : Raviprakash Tumkur Sitaram; Göran Roos; Anders Bjartell; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; DJ-1; NBS1; PTEN; WT1; cMyc; hTERT; telomerase; Pathology; Patologi; patologi; Pathology;

    Abstract : Telomerase is a ribonucleoprotein complex that catalyses telomeric repeat addition at the ends of chromosomes. The catalytic subunit, hTERT, acts as a key determinant for telomerase activity control; the induction of hTERT expression is required for telomerase activity. READ MORE

  4. 2. Radioimmunotherapy in Experimental Head and Neck Squamous Cell Carcinoma : Tumour-targeting in vitro and in vivo

    Author : Junping Cheng; Matti Anniko; Mats Engström; Vladimir Tolmachev; Torgny Stigbrand; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otorhinolaryngology; squamous cell carcinoma; radioimmunotherapy; cell line; tumour targeting; radionuclide; nude mice; Otorhinolaryngologi; Otorhinolaryngology; Otorhinolaryngologi;

    Abstract : Radioimmunotherapy (RIT) has been shown to be a practicable way to treat head and neck squamous cell carcinoma. A specific antibody recognizes the charasteristic structure of tumour cells when loaded with cytotoxic agents (toxins, drugs, radionuclides, etc). READ MORE

  5. 3. Angiogenesis in human renal cell carcinoma : hypoxia, vascularity and prognosis

    Author : Johanna Sandlund; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Anders Bergh; Elisabeth Kjellén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endoglin CD105; CD31; prognosis; CA IX; HIF-2α; renal cell carcinoma; tissue microarray; immunohistochemistry; real-time PCR; stage; grade; Oncology; Onkologi;

    Abstract : Background: Angiogenesis is recognised as a critical step in tumour progression. The angiogenic switch is activated by various trigger signals, such as hypoxia, low pH, and genetic mutations. Renal cell carcinoma (RCC) is often an aggressive tumour, and advanced disease has limited treatment options and bad prognosis. READ MORE

  6. 4. Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development

    Author : Martin Thelin; Matrixbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; iduronic acid; chondroitin sulfate; esophagus squamous cell carcinoma; cancer; MET receptor; dermatan sulfate; hepatocyte growth factor; DS-epimerase 2; DS-epimerase 1;

    Abstract : Cell behavior such as migration and proliferation, especially during cancer development, are balanced by the surrounding environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. READ MORE

  7. 5. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Author : Fredrik Persson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Abstract : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. READ MORE