Search for dissertations about: "cardiac myopathy"
Showing result 1 - 5 of 9 swedish dissertations containing the words cardiac myopathy.
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1. Welander distal myopathy : clinical and genetic studies
Abstract : Distal myopathies are a group of muscular disorders described in many countries with different inheritance patterns and variable progression rates. Welander distal myopathy (WDM) is characterised by autosomal dominant inheritance, late onset and distal distribution of muscular weakness. Most cases originate from the middle parts of Sweden. READ MORE
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2. Genetic and pathophysiological study of desmin derangements in cardiac disorders
Abstract : Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from mechanical stress during contractionrelaxation process. READ MORE
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3. Cellular studies of neuromuscular disorders related to the sarcomeric proteins
Abstract : Sarcomere is the basic unit of cardiac and skeletal muscle contraction and its proper function requires an invariant organization of this structure. Mutations in sarcomeric proteins are known to cause increasing number of different cardiac and skeletal muscle diseases. READ MORE
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4. Structure and function of the cytoskeleton in cardiac and skeletal muscle
Abstract : We have examined the functional and structural roles of the cytoskeletal protein desmin in cardiac and skeletal muscles using a genetically modified mouse (Des-/-) with the desmin gene ablated. Desmin forms filaments at the Z-disks in the striated muscle sarcomere, have connections to the sarcolemma and most likely align sarcomeres and whole cells. READ MORE
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5. Mitochondria, contractility and Ca2+ handling : cardiac and skeletal muscle adaptations in health and disease
Abstract : Contractility is a fundamental feature of skeletal and cardiac muscles. An indispensable step in the cellular signal for contraction is a transient elevation in cytoplasmic free [Ca2+] ([Ca2+]i). Both the production of contractile force and Ca2+ handling processes are highly energy demanding. READ MORE