Search for dissertations about: "cardiomyocytes"
Showing result 21 - 25 of 56 swedish dissertations containing the word cardiomyocytes.
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21. Cardiac lipids and their role in the diseased heart
Abstract : Lipids play an essential role within the heart as they are involved in energy storage, membrane stability and signaling. Changes in cardiac lipid composition and utilization may thus have profound effects on cardiac function. Importantly, the diseased heart is associated with intracellular metabolic abnormalities, including accumulation of lipids. READ MORE
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22. Site and Mechanism of Action of Resin Acids on Voltage-Gated Ion Channels
Abstract : Voltage-gated ion channels are pore-forming membrane proteins that open or close their gates when the voltage across the membrane is changed. They underlie the electrical activity that enables the heart to pump blood and the brain to receive and send signals. READ MORE
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23. A modular mRNA approach to study and treat phospholamban mediated cardiomyopathies
Abstract : In the heart, phospholamban (PLN) is a key regulator of calcium cycling through its inhibitory effect on the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. For more than two decades, modulating calcium channels has been a strong focus of prospective cardiac therapeutics with a recent emphasis on targeting PLN itself, partially due to the progressive uncovering of several cardiomyopathic PLN human mutations. READ MORE
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24. The pathophysiology of respiratory chain dysfunction
Abstract : Mutations of mitochondrial DNA cause a variety of clinical syndromes. It is unclear whether impaired oxidative phosphorylation on its own is the main cause of pathology or whether other factors such as secondary metabolic alterations, enhanced formation of reactive oxygen species (ROS) and induction of apoptosis also may contribute to the clinical phenotype. READ MORE
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25. Ca2+ fluxes and insulin action in cardiac and skeletal muscles
Abstract : Obesity and type 2 diabetes are major and rapidly increasing health problems in society. They are associated with several life-threatening conditions, including heart and renal failure, and damage to the nervous system. An inability of cells to respond normally to insulin, insulin resistance, is a key feature in obesity and type 2 diabetes. READ MORE