Search for dissertations about: "cardiovascular genetics"
Showing result 1 - 5 of 78 swedish dissertations containing the words cardiovascular genetics.
-
1. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry
Abstract : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. READ MORE
-
2. Cardiovascular Risk Genes in Prevention and Treatment Response
Abstract : GENERAL AIM: To investigate how common single-nucleotide-polymorphisms (SNPs) that associate with cardiovascular disease (CVD) could be used in prevention and treatment of CVD. SUBJECTS: Subjects from the population-based Malmö-Diet-and-Cancer-(MDC)-Study (n=30447) and hypertensives from the Nordic-Diltiazem-(NORDIL)-Study (n=10881). READ MORE
-
3. Genetic studies on cardiovascular disease - identification of novel drug targets
Abstract : The aim of this thesis was to identify novel potential drug targets of cardiovascular disease with a focus on G-protein coupled receptors. We identified a common genetic variant of the ATP receptor P2Y11, where an alanine is substituted with a threonine at position 87 of the P2Y11 receptor that increases the risk of developing acute myocardial infarction. READ MORE
-
4. Genetic studies in rheumatoid arthritis : familial studies and analysis of relationships to atherothrombotic comorbidity
Abstract : Background. Rheumatoid arthritis (RA) is an autoimmune disease mainly affecting the joints but has also extra articular manifestations and an increased cardiovascular (CV) co-morbidity. Rheumatoid factor (RF) and antibodies against citrullinated proteins/peptides (ACPA) are diagnostically important and are related to a more severe disease. READ MORE
-
5. Genetic predisposition to salt sensitivity and cardiovascular disease
Abstract : Abstract The average amount of salt ingested is about 10 grams daily compared to less than one gram in pre-historic life. Salt, althought somewhat debated, is considered a risk factor for elevated blood pressure and end organ damage beyond the blood pressure effect. READ MORE