Search for dissertations about: "carrier-mediated transport"

Showing result 1 - 5 of 8 swedish dissertations containing the words carrier-mediated transport.

  1. 1. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erik Sjögren; Uppsala universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; Biofarmaci;

    Abstract : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. READ MORE

  2. 2. Membrane transport of triiodothyronine : With particular reference to erythrocytes in health and disease

    University dissertation from Linköping : Linköpings universitet

    Author : Ann-Charlotte Holm; Linköpings universitet.; Linköpings universitet.; [1992]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Cellular T3 uptake was studied in three human cell systems, i.e. cultured lymphocytes, erythrocytes and erythrocyte membrane vesicles. READ MORE

  3. 3. Intestinal transport of levodopa : Implications for the therapy of Parkinson's disease

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Dag Nilsson; Uppsala universitet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Parkinson s disease; levodopa. duodenal Infusion; intestinal permeability; positron emission tomography; Neurovetenskap; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Internal medicine Neurology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Invärtesmedicin Neurologi; Neurology; neurologi;

    Abstract : Levodopa has been the basic treatment of patients with Parkinson's disease for the last 30 years. However, with time nearly all patients develop fluctuations in motor performance correlated to levodopa plasma concentrations. READ MORE

  4. 4. GABA and human spermatozoa : characterization and regulation of GABA transport proteins

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Arthur Aanesen; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GABA; spermatozoa; GABA transport; acrosome reaction; sperm motility; progesterone; protein kinase C; GAT-1; GAT-2; GAT-3; BGT-1;

    Abstract : The present project aimed at investigating the interaction between GABA and human spermatozoa under in vitro conditions. Our initial hypothesis was that human spermatozoa had specific binding proteins for GABA and that the binding of GABA to such binding sites could affect sperm fimction. READ MORE

  5. 5. Distribution of antiviral nucleoside analogues into brain and skin

    University dissertation from Stockholm : Karolinska Institutet, Department of Laboratory Sciences and Technology

    Author : Natalia Borg; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The aim of this thesis was to study physiological and physico-chemical factors influencing the pharmacokinetics and distribution over the blood-brain barrier of antiviral nucleoside analogues in the rat, and to study the distribution to the human skin in vivo of an anti-herpetic nucleoside analogue. Microdialysis was used to sample the free (unbound) extracellular concentration of the nucleoside analogues from the brain tissue, muscle and blood in the rat and from the dermis of healthy human volunteers. READ MORE