Search for dissertations about: "cart"

Showing result 1 - 5 of 38 swedish dissertations containing the word cart.

  2. 1. The role of CART in islet function

    Author : Mia Abels; Neuroendokrin cellbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cocaine- and amphetamine-regulated transcript; CART; Diabetes; T2D; Human islets; Glucagon; Insulin; Adipocyte;

    Abstract : Diminished insulin secretion and dysregulated glucagon secretion are key features of type 2 diabetes (T2D). The overall aim of this thesis was to study the role of cocaine- and amphetamine-regulated transcript (CART) in islet cell function and how CART regulates glucose homeostasis. READ MORE

  4. 2. Ghrelin and CART. Two new islet peptides. Expression, regulation and function

    Author : Nils Wierup; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; diabetology; histology; endocrinology; islets; CART; Ghrelin cells; insulin secretion; type-2 diabetes; Ghrelin;

    Abstract : Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. READ MORE

  5. 3. Influence of Islet-derived Factors in Islet Microcirculation and Endocrine Function

    Author : Carl Johan Drott; Per-Ola Carlsson; Leif Jansson; Albert Salehi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes mellitus; pancreas; blood flow; islet vascularity; islet-derived; TSP-1; ghrelin; CART; irisin; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Diabetes mellitus is a disorder with complex pathology and is frequently associated with vascular complications. In the islet micro milieu locally generated factors may affect both the physiology and the morphology of the tissue. READ MORE

  6. 4. Physiological Studies of Native and Stem Cell-Derived Islets

    Author : Daniel Norman; Per-Ola Carlsson; Daniel Espes; Helge Ræder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Irisin; CART; Islet blood flow; Islets of Langerhans; Stem cell-derived islets; Fysiologi; Physiology; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : In type 1 and type 2 diabetes, the β-cells of the islets of Langerhans are either destroyed by the immune system or stressed due to peripheral insulin resistance. To improve the life of patients with these diseases, new treatments are needed. READ MORE

  7. 5. Hirschsprung´s Disease & Gastroesophageal Reflux. Aspects on Two Gastrointestinal Motility Disorders in Childhood

    Author : Anna Gunnarsdottir; Neurogastroenterologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GERD; Gastroesophageal Reflux; Duhamel pull-through; TERPT; Quality of Life; ENS; CART; Hirschsprung´s Disease; GER; pH-monitoring; Wireless; BRAVO;

    Abstract : Gastrointestinal motility disorders are common in childhood and in this thesis we look at two of them, i.e. Hirschsprung´s Disease (HD) and gastroesophageal reflux disease (GERD) in five different studies. READ MORE