Search for dissertations about: "cartilage degradation"

Showing result 1 - 5 of 24 swedish dissertations containing the words cartilage degradation.

  2. 1. Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly

    Author : Anna Johnson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; COMP; Perlecan; chondroadherin; cartilage; ECM; Medicin människa och djur ;

    Abstract : The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. READ MORE

  4. 2. Interactions between extracellular matrix proteins and the complement system - In the perspective of cartilage degradation in inflammatory joint diseases

    Author : Camilla Melin Fürst; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complement system; rheumatoid arthritis; osteoarthritis; extracellular matrix; cartilage degradation; mass spectrometry;

    Abstract : Abstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role in promoting the joint inflammation in these diseases. READ MORE

  5. 3. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

    Author : Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

    Abstract : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. READ MORE

  6. 4. Three-dimensional T1 quantification techniques for assessment of cartilage quality using dGEMRIC

    Author : Carl Siversson; Malmö Medicinsk strålningsfysik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B1; T1; MRI; 3D; correction; dGEMRIC; cartilage; Look-Locker; Variable Flip Angle;

    Abstract : Osteoarthritis (OA) is a common chronic disease and one of the major global causes for functional disabilities. The disease is characterized by loss and degradation of cartilage, commonly affecting the knees and hips. READ MORE

  7. 5. Metabolism of articular cartilage proteoglycans in vitro : effects of synovial membrane products and mechanical pressure

    Author : Agneta Klämfeldt; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Articular cartilage; Proteoglycan metabolism; Synovial membrane products; Mechanical stress; Indom ethacin; Glucocorticoids; Prostaglandins; Osteoarthritis; Rheumatoid arthritis;

    Abstract : The effect of synovial membrane products and mechanical pressure upon the metabolism of articular cartilage proteoglycans has been studied in vitro. The degradation of cartilage proteoglycans was studied in an organ culture system and measured as the release of [35S ] sulphate from prelabelled cartilage. READ MORE