Search for dissertations about: "cartilage destruction"

Showing result 16 - 20 of 35 swedish dissertations containing the words cartilage destruction.

  2. 16. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis

    Author : Li Bian; Göteborgs universitet; []
    Keywords : S100A4; arthritis; animal model; bone; inflammation;

    Abstract : S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high incidence of metastasis of cancers. READ MORE

  4. 17. HMGB1 in inflammation : secretion and function

    Author : Heidi Wähämaa; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by progressive joint destruction. The inflammatory and joint destructive processes in RA are mediated by resident synovial cells and cells recruited from the blood stream and bone marrow. READ MORE

  5. 18. Interleukin 15 and 17 in Staphylococcus aureus arthritis

    Author : Louise Henningsson; Göteborgs universitet; []
    Keywords : Staphylococcus aureus; Interleukin-17A; Interleukin-15; arthritis; osteoclasts; IL-23;

    Abstract : Staphylococcus aureus–induced arthritis leads to severe joint destruction and high mortality despite antibiotic treatment. Thus, there is a need to identify new treatment targets in addition to antibiotic therapy. Interleukin (IL)-15 has been implicated both in osteoclastogenesis and in bacterial clearance – two important issues in S. READ MORE

  6. 19. Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis

    Author : Mohammed Mullazehi; Johan Rönnelid; Bosse Nilsson; Kutty Selva Nandakumar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical immunology; Klinisk immunologi; Klinisk immunologi; Clinical Immunology;

    Abstract : Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. READ MORE

  7. 20. Arthritis and immune-mediated bone loss - role of estrogen signalling pathways

    Author : Cecilia Engdahl; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; Bone; Estrogen;

    Abstract : Objective: Rheumatoid arthritis (RA) is associated with immune-mediated bone loss and thereby increased risk for fractures. Estrogen and selective estrogen receptor modulators (SERMs) ameliorate not only the incidence and progression of experimental RA but also the immune-mediated bone loss. READ MORE