Search for dissertations about: "cartilage destruction"

Showing result 6 - 10 of 35 swedish dissertations containing the words cartilage destruction.

2. 6. Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies

   Author : Rüdiger J Weiss; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Background: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic polyarticular synovial inflammation. Erosive joint destruction represents a major unsolved complication of RA. Objectives: The aim of this thesis was to obtain increased knowledge of joint destruction by using a multidisciplinary approach. READ MORE

4. 7. Immunopathogenic studies on inflammation and bone destruction in rheumatoid arthritis

   Author : Shankar Kumar Revu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Rheumatoid arthritis (RA) is a chronic systemic joint disease characterized by synovial inflammation, leading to destruction of cartilage and bone. Local recruitment of immune cells and defective apoptosis results in chronic inflammation with increased synovial citrullination and local hypoxia. READ MORE

5. 8. Hormone replacement therapy in rheumatoid arthritis

   Author : Helena Forsblad d'Elia; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rheumatoid arthritis; randomised controlled trials; hormone replacement therapy; estrogen; osteoporosis; bone mineral density; bone remodelling; cartilage remodelling; cytokines; insulin-like growth factor 1;

   Abstract : Rheumatoid arthritis (RA) is 2-3 times more frequent in women as compared to men. The peak incidence in women coincides with the years around the menopause and the course of RA is also influenced by events associated with hormonal alterations. READ MORE

6. 9. Early rheumatoid arthritis : biomarkers and hormonal factors in relation to disease progression

   Author : Antonia Boman; Solbritt Rantapää-Dahlqvist; Ewa Berglin; Gerd-Marie Alenius; Mikael Brink; Heidi Kokkonen; Inger Gjertsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Early rheumatoid arthritis; biomarker; ACPA; RANKL; disease activity; radiological destruction; cardiovascular events; hormonal factors; reumatologi; rheumatology;

   Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, affecting approximately 0.5 to 1% of the adult population. Although the aetiology is not fully known, a complex interaction between genetic, environmental and stochastic factors is thought to trigger the pathogenic mechanisms. READ MORE

7. 10. Analysis of antibodies to cartilage oligomeric matrix protein in rheumatoid arthritis and in mouse models

   Author : Weiwei Cai; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Rheumatoid arthritis (RA), a common autoimmune disease, affects 0.5-1% of the world’s population. It is not only an important health problem but also a socioeconomic problem considering that it can lead to joint destruction and disability. It is well known that the disease can actually start many years ahead of the clinical onset. READ MORE