Search for dissertations about: "caspases"

Showing result 11 - 15 of 75 swedish dissertations containing the word caspases.

2. 11. Mechanisms and mediators of apoptosis : with special reference to hematological disorders

   Author : Bengt Fadeel; Karolinska Institutet; Karolinska Institutet; []
   Keywords : apoptosis; Bcl-2; caspases; chemotherapy; chronic granulomatous disease; familial hemophagocytic lymphohistiocytosis; Fas; homology-based modeling; neutrophils; phosphatidylserine; reactive oxygen species;

   Abstract : Life and death are inextricably entwined. Naturally occurring cell death or apoptosis is essential for the of homeostasis and serves to remove extraneous or dangerous cells in a swift and unobtrusive manner. work has demonstrated that such cell death is genetically regulated and transpires according to evolutionarily conserved pathways. READ MORE

4. 12. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

   Author : Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. READ MORE

5. 13. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma

   Author : Jenny Karlsson; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; neuroblastoma; multidrug resistance; hypoxia; glucose-deficiency; cell death; Bax; Apoptosis; arsenic trioxide;

   Abstract : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. READ MORE

6. 14. Studies on caspase signaling in microglia

   Author : Johanna Rodhe; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The aim of this thesis is to investigate the roles of caspase-8 and caspase-3 in microglia and in brain disorders, beyond their function in apoptosis. Microglia are resident immune cells of the central nervous system and act as the first line of defense against invading pathogens and other types of brain insults. READ MORE

7. 15. DNA damage-induced cell death : the role of caspase-2

   Author : Helin Vakifahmetoglu; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

   Abstract : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. READ MORE