Search for dissertations about: "caspases"
Showing result 16 - 20 of 75 swedish dissertations containing the word caspases.
-
16. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia
Abstract : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. READ MORE
-
17. Computational Prediction Models for Proteolytic Cleavage and Epitope Identification
Abstract : The biological functions of proteins depend on their physical interactions with other molecules, such as proteins and peptides. Therefore, modeling the protein-ligand interactions is important for understanding protein functions in different biological processes. READ MORE
-
18. The role of the mitochondrion in organotin-induced T-cell apoptosis
Abstract : Apoptosis plays a central role in the development and the function of the immune system. The cell death program can, however, be inappropriately activated or suppressed under pathological conditions. Several toxins have been shown to interfere with intra-thymic processes, thereby contributing to autoimmune disorders. READ MORE
-
19. Thiol redox state in apoptosis : physiological and toxicant modulation
Abstract : Apoptosis is a physiological type of cell death used to regulate the number of cells during development and in adult organs. However, apoptosis can also be inappropriately activated or inhibited under pathological conditions. One of the critical mechanisms of apoptosis is the activity of cysteine proteases belonging to the caspase family. READ MORE
-
20. In vitro models to study mechanisms of neural cell death induced by toxic agents
Abstract : Neurotoxicity arises when exposure to toxic agents, either naturally occurring or manmade substances, alters the normal activity and/or structure of the nervous system. This can lead to disruption of vital metabolic processes and eventually to cell death. Certain unique features of the nervous system make it particularly vunerable to toxicants, e. READ MORE