Search for dissertations about: "catalepsy"
Showing result 1 - 5 of 10 swedish dissertations containing the word catalepsy.
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1. Serotonergic mechanisms in neuroleptic-induced catalepsy in the rat : implications for the mechanism of action of atypical antipsychotic drugs
Abstract : .... READ MORE
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2. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia
Abstract : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. READ MORE
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3. On the mechanisms of action of atypical antipsychotic drugs : an experimental study
Abstract : A majority of schizophrenic patients respond to classical neuroleptic drugs which are believed to act largely via blockade of dopamine (DA) D2 receptors in limbic structures. However, a significant proportion do not respond to conventional D2 receptor blocking drugs or show a rather incomplete therapeutic effect, particularly on negative and cognitive symptoms. READ MORE
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4. Novel pharmacological treatment alternatives for schizophrenia
Abstract : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. READ MORE
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5. Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
Abstract : Dopamine is fundamental in human behavior for movement, cognition and reward. A dysfunctional dopamine system is implicated in several neurological and psychiatric disorders such as Parkinson s disease and schizophrenia. Dopamine mediates its effects through five receptors. READ MORE