Search for dissertations about: "catalytic mechanism"

Showing result 21 - 25 of 360 swedish dissertations containing the words catalytic mechanism.

  2. 21. Studies of native and Cd(II)-substituted carbonic anhydrases with special reference to their interaction with inhibitors

    Author : Lena Tibell; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbonic anhydrase; Cd II ; 113-Cd II -NMR; inhibition; catalytic mechanism;

    Abstract : The major aim of this work has been to gain further insights into the catalytic mechanism of carbonic anhydrase (carbonate hydro-lyase, EC 4.2.1.1). READ MORE

  4. 22. Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles : A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

    Author : Wei Zhang; Bengt Mannervik; Bengt-Harald Jonsson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; azathioprine; directed evolution; semi-rational design; catalytic mechanism; saturation mutagenesis; reduced amino acid alphabets; molecular docking; protein evolution; multivariate data analysis; epistasis; fitness landscape; evolutionary trajectories; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : Directed evolution is generally regarded as a useful approach in protein engineering. By subjecting members of a mutant library to the power of Darwinian evolution, desired protein properties are obtained. Numerous reports have appeared in the literature showing the success of tailoring proteins for various applications by this method. READ MORE

  5. 23. Quantum Chemical Modeling of Binuclear Zinc Enzymes

    Author : Shilu Chen; Fahmi Himo; Luca De Gioia; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Quantum Chemical Modeling; Binuclear; Zinc; Enzyme; DFT; Mechanism; Theoretical chemistry; Teoretisk kemi;

    Abstract : In the present thesis, the reaction mechanisms of several di-zinc hydrolases have been explored using quantum chemical modeling of the enzyme active sites. The studied enzymes are phosphotriesterase (PTE), aminopeptidase from Aeromonas proteolytica (AAP), glyoxalase II (GlxII), and alkaline phosphatase (AP). READ MORE

  6. 24. Stepping into Catalysis : Kinetic and Mechanistic Investigations of Photo- and Electrocatalytic Hydrogen Production with Natural and Synthetic Molecular Catalysts

    Author : Daniel Streich; Leif Hammarström; Reiner Lomoth; Clifford Kubiak; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Artificial photosynthesis; photocatalysis; electrocatalysis; hydrogen production; proton reduction; hydrogenase; iron complex; active site model; catalytic mechanism; transient absorption; spectroscopy; electrochemistry; cyclic voltammetry; Kemi med inriktning mot kemisk fysik; Chemistry with specialization in Chemical Physics;

    Abstract : In light of its rapidly growing energy demand, human society has an urgent need to become much more strongly reliant on renewable and sustainable energy carriers. Molecular hydrogen made from water with solar energy could provide an ideal case. READ MORE

  7. 25. Mechanism Studies of Catalytic RNA, and RNA and DNA Model Compounds

    Author : Ethel Pettersson; Eric Westhof; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Abstract : This thesis describes mechanism studies of transesterifications of phosphate esters. The aim of the studies concerns two fields. First, the catalytic mechanism that group I introns use in self-splicing. The focus was on metal ion coordinating groups at the catalytic site. READ MORE