Search for dissertations about: "catalytically active"

Showing result 11 - 15 of 90 swedish dissertations containing the words catalytically active.

  2. 11. Enzyme Cold Adaptation through Evolution of Protein Flexibility

    Author : Jaka Sočan; Johan Åqvist; Hugo Gutiérrez-de-Terán; Janez Mavri; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EVB; Empirical valence bond method; Pancreatic elastase; α-amylase; Enzyme catalysis; Enzyme evolution; Cold adaptation; Temperature dependence of catalytic rates; Psychrophilic enzyme; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : What lives, evolves. Macromolecular catalysis is a process, central to both evolutionary and metabolic aspect of life, as it provides a systematic bias favouring certain chemical processes. READ MORE

  4. 12. Studies on mitochondrial adenosine triphosphatase : uncoupler-reversible inhibition of mitochondrial ATPase and related enzymes by metal chelates of bathophenenthroline

    Author : Christine Carlsson-Skwirut; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The mitochondrial ATPase constitutes the terminal enzyme of oxidative phosphorylation and is, together with similar enzymes present in chloroplasts and bacteria, responsible for the synthesis of ATP from ADP and Pi during electron transport. The enzyme consists of an extrinsic, catalytically active part, called Fl, that is structurally and functionally linked to an intrinsic, proton-translocating device, called Fo. READ MORE

  5. 13. Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation

    Author : Martin J Mueller; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotriene (LT) A4 hydrolase catalyzes the committed step in the biosynthesis of LTB4, a classical chemoattractant and immuine-modulating lipid mediator involved in inflammation, host-defense against infections, and systemic, PAF-mediated, lethal shock. LTA4 hydrolase is a bifunctional zinc metalloenzyme with a chloride stimulated arginyl aminopeptidase activity. READ MORE

  6. 14. Role of Multiple Glutathione Transferases in Bioactivation of Thiopurine Prodrugs : Studies of Human Soluble Glutathione Transferases from Alpha, Kappa, Mu, Omega, Pi, Theta, and Zeta Classes

    Author : Birgitta I. Eklund; Bengt Mannervik; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Keywords : Biochemistry; Glutathione Transferases; Thiopurines; Prodrug; Bioactivation; Screening Method; Chemotherapy; Functional plasticity; Modulated activity; Biokemi;

    Abstract : A screening method was developed for identification of catalytically active enzymes in combinatorial cDNA libraries of mutated glutathione transferase (GST) derivatives expressed in E. coli. The method is based on spraying monochlorobimane (MCB) directly over bacterial colonies growing on agar. READ MORE

  7. 15. Lipases as Biocatalysts in Organic Media. Influence of Enzyme Preparation and Reaction Conditions on Activity and Selectivity

    Author : Mattias Persson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biochemical technology; Bioteknik; Biotechnology; water activity; temperature; enantioselectivity; immobilisation; organic solvents; lyophilisation; Lipases; Accurel EP-100; Biokemisk teknik; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : The discovery that enzymes can function in organic solvents has broadened the scope of biocatalysis, making enzymes highly useful tools for organic chemists. The widespread use of enzymes as catalysts in organic solvents has, however, been limited by the low activity obtained for enzymes in organic solvents compared to aqueous solutions. READ MORE