Search for dissertations about: "cathepsin D"

Showing result 1 - 5 of 31 swedish dissertations containing the words cathepsin D.

  2. 1. Cathepsin D released from lysosomes mediates apoptosis

    Author : Katarina Kågedal; Marja Jäättelä; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Last year (2002), the Nobel Prize in Physiology or Medicine was awarded to three scientists who have conducted pioneer research on programmed cell death. In the human body, more than a thousand billion cells are created every day, and an equal number die, thus programmed cell death, or apoptosis, is an important mechanism for maintaining tissue homeostasis and protecting against disease. READ MORE

  4. 2. Immunocytochemical visualization of cathepsin D during oxidative stress

    Author : Karin Roberg; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Cathepsin D is the major aspartic protease in lysosomes, and it is found in almost all animal cells. In the present studies, a pre-embedding immunocytochemical method was used to visualize cathepsin D in cultured cells. The protein can be detected at both light and electron microscopic levels by neutral-pH silver enhancement of ultrasmall (0. READ MORE

  5. 3. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice

    Author : Hanna Wootz; Dan Lindholm; Håkan Aldskogius; Christopher Fowler; Uppsala universitet; []
    Keywords : Neurosciences; ALS; Caspase; Caspase-12; Cathepsin; Cystatin; ER stress; Motor neuron; Neurodegeneration; Sod1; XIAP; Neurovetenskap;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE

  6. 4. Metal homeostasis as critical determinant for cellular fitness

    Author : Jutta Diessl; Sabrina Büttner; Rajini Rao; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metal homeostasis; manganese toxicity; coenzyme Q synthesis; mitochondrial respiration; calcineurin signaling; Pmr1; SPCA1; calcium; survival; caloric restriction; Parkinson’s disease models; proteotoxicity; Pep4; cathepsin D; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Metals play a crucial role in cellular biology. Bulk and trace metals such as calcium and manganese regulate a plethora of cellular processes ranging from signaling and oxidative stress to proteostasis and energy metabolism. READ MORE

  7. 5. The role of cathepsin D in apoptosis induced by oxidative stress

    Author : Karin Roberg; Adi Kimchi; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The lysosomal protease cathepsin D is translocated from lysosomes to the cytosol during apoptosis induced by oxidative stress. In the present studies, the redox-cycling, xenobiotic compound naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was used to create oxidative stress in rat cardiomyocytes and human foreskin fibroblasts. READ MORE