Search for dissertations about: "cathepsin d inhibitors"
Showing result 1 - 5 of 9 swedish dissertations containing the words cathepsin d inhibitors.
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1. Amyotrophic Lateral Sclerosis – A Study in Transgenic Mice
Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an incidence of 1.5-2.7/100000 people/year. Today there is no cure for the disease and only symptomatic treatments are available. READ MORE
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2. Design and Synthesis of BACE-1 Inhibitors : Novel Compounds Targeting an Aspartic Protease Important in the Pathogenesis of Alzheimer’s Disease
Abstract : This thesis deals with the design and synthesis of protease inhibitors targeting the aspartic protease BACE-1 (β-site APP cleaving enzyme-1), an enzyme important in the pathogenesis of Alzheimer’s disease. The inhibitors are evaluated with respect to inhibition data, in a structure-activity relationship part. READ MORE
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3. Design and synthesis of aspartyl protease inhibitors : Targeting HIV-1 and malaria plasmepsin I and II
Abstract : Aspartyl proteases can generally be inhibited by peptide mimics containing an uncleavable peptide bond isostere at the proposed cleavage site. One such peptide bond isostere is the hydroxyethylamine moiety, which in this thesis has successfully been incorporated in potential inhibitors of the HIV-1-protease as well as the malarial proteases plasmepsin I and II. READ MORE
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4. Design and Synthesis of Malarial Aspartic Protease Inhibitors
Abstract : Malaria is one of the major public health problems in the world. Approximately 500 million people are afflicted and almost 3 million people die from the disease each year. Of the four causative species Plasmodium falciparum is the most lethal. READ MORE
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5. Binding Free Energy Calculations on Ligand-Receptor Complexes Applied to Malarial Protease Inhibitors
Abstract : Malaria is a widespread disease caused by parasites of the genus Plasmodium. Each year 500 million clinical cases are reported resulting in over one million casualties. The most lethal species, P. falciparum, accounts for ~90% of the fatal cases and has developed resistance to chloroquine. READ MORE