Search for dissertations about: "cathepsins"

Showing result 1 - 5 of 20 swedish dissertations containing the word cathepsins.

  2. 1. Lysosomal Membrane Permeabilization : A Cellular Suicide Strategy

    Author : Ann-Charlotte Johansson; Karin Öllinger; Karin Roberg; Boris Zhivotovsky; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; lysosomes; lysosomal membrane permeabilization; cathepsins; Bax; Bid; mitochondria; caspases; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis signaling and execution has been achieved.The aim of this thesis was to clarify the role of lysosomal membrane permeabilization and lysosomal proteases, cathepsins, in signaling for apoptosis. READ MORE

  4. 2. Structural and Functional Studies on Human Type 2 Cystatins

    Author : Marcia Alvarez Fernandez; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; Klinisk kemi; structural- functional relationships.; protein crystallography; enzyme kinetics; inhibitors; cathepsins; legumains; cystatins; cysteine peptidases;

    Abstract : Proteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. READ MORE

  5. 3. Lysosomal Membrane Stability and Cathepsins in Cell Death

    Author : Hanna Appelqvist; Karin Öllinger; Katarina Kågedal; Petra Wäster; Maria Shoshan; Linköpings universitet; []
    Keywords : ;

    Abstract : Lysosomes are acidic organelles that are critically involved in a number of physiological processes, including macromolecule degradation, endocytosis, autophagy, exocytosis and cholesterol homeostasis. Several pathological conditions, such as cancer, neurodegenerative disorders and lysosomal storage diseases, involve lysosomal disturbances, indicating the importance of the organelle for correct cellular function. READ MORE

  6. 4. Regulation of UV induced apoptosis in human melanocytes

    Author : Cecilia Bivik; Inger Rosdahl; Karin Öllinger; Maria Shoshan; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; apoptosis; UV; melanocyte; lysosome; cathepsin; Bcl-2; Bax; Hsp70; JNK; Dermatology and venerology; Dermatologi och venerologi;

    Abstract : Malignant melanoma arises from the pigment producing melanocytes in epidermis and is the most aggressive type of skin cancer. The incidence of malignant melanoma is increasing faster than any other type of cancer in white population worldwide, with a doubling rate every 10-20 years. READ MORE

  7. 5. Oxidized Lipids and Lysosomal Pathology in Atherogenesis

    Author : Wei Li; Wendy Jessup; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Macrophages take up large amount of exogenous materials such as oxidatively modified low-density lipoproteins (oxLDL) and lysosomotropic agents. OxLDL is taken up into macrophage lysosomes through receptor-mediated endocytosis, but poorly degraded, resulting in foam cell formation. READ MORE