Search for dissertations about: "cationic scaffold"

Showing result 1 - 5 of 6 swedish dissertations containing the words cationic scaffold.

  2. 1. Aspects of DNA Strand Exchange: Recombination Proteins and Model System Studies

    Author : Karolin Frykholm; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; DNA strand exchange; cationic liposome; Rad51; Site-Specific Linear Dichroism; RecA; molecular crowding;

    Abstract : DNA recombination is of fundamental importance to all living cells; it is part of the DNA repair machinery and a means to generate genetic diversity. DNA strand exchange, the exchange of strands between homologous DNA molecules, is the central reaction of the recombination process. READ MORE

  4. 2. RNA in model lipid membranes - interactions in bulk and at surfaces

    Author : Agnes Michanek; Fysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ssRNA; RNA origami; dsDNA; selfassembly phospholipids; model membranes; monolayer; QCM-D; DSC; Neutron reflectometry; hydrophobic interaction; cationic surfactants; sphingosine; phase behavior;

    Abstract : The work presented in the thesis “RNA in model lipid membranes- interactions in bulk and at surfaces” aims to characterize the interaction between RNA and model membranes with different properties as well as to determine if ssRNA associate with model membranes in different ways. Several techniques have been used to characterize these systems, including quartz crystal microbalance with dissipation monitoring (QCM-D), Langmuir film balance in combination with neutron reflectometry and fluorescence microscopy as well as differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC). READ MORE

  5. 3. METAL CARBONYL MEDIATED REACTIONS - APPLICATIONS IN THE SYNTHESIS OF POTENTIAL GALECTIN INHIBITORS

    Author : Nuria Parera Pera; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : AbstractThis work reports the development of an asymmetric version of the Nicholas reaction using monodentate phosphoramidites as ligands, which enables asymmetric synthesis from racemic starting material. In addition, we describe the application of metal carbonyl mediated reactions, such as the Pauson-Khand reaction (PKR) and reactions involving cationic iron carbonyl dienyl complexes, for the synthesis of potential galectin inhibitors, implicated in human inflammatory responses and various pathologies. READ MORE

  6. 4. Development of oligonucleotide based artificial ribonucleases 2'-O-MeOBAN´s and PNAzymes

    Author : Merita Murtola; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The present thesis is based on three parts. The first and second part describe the development of two different classes of metal-ion dependent artificial ribonucleases, 2'-O-methyl-ribonucleic acid based artificial ribonucleases (2'-O-MeOBANs) and peptide nucleic acid based artificial ribonucleases (PNAzymes). READ MORE

  7. 5. Identification and characterization of novel virulence factors in Streptococcus pneumoniae

    Author : Florian Wartha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Streptococcus pneumoniae (the pneumococcus) is a major human pathogen with high morbidity and mortality worldwide. Increased antibiotic resistance and insufficient vaccination contribute to the re-emerging of this pathogen. READ MORE