Search for dissertations about: "causes of Alzheimer’s disease"

Showing result 1 - 5 of 49 swedish dissertations containing the words causes of Alzheimer’s disease.

  2. 1. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

    Author : María Pagnon de la Vega; Martin Ingelsson; Dag Sehlin; Vilmantas Giedraitis; Gunnar Gouras; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; neurodegeneration; amyloid precursor protein; APP processing; amyloid beta; transgenic mouse model;

    Abstract : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. READ MORE

  4. 2. Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

    Author : Ola Philipson; Lars Nilsson; Lars Lannfelt; Fred van Leuven; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid; Amyloid-β; intraneuronal; transgenic mice; immunohistochemistry; ELISA; Public health medicine research areas; Folkhälsomedicinska forskningsområden; Geriatrics; Geriatrik;

    Abstract : The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new insights into the mechanisms of early (pre-plaque) and late-stage Aβ pathogenesis in AD. READ MORE

  5. 3. Synthesis of Ring-fused Peptidomimetics : Interacting with Amyloid Fibrils

    Author : Dan E. Adolfsson; Fredrik Almqvist; Anna Linusson; Morten Grötli; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; organic chemistry; synthesis; peptidomimetics; thiazoline fused 2-pyridones; Alzheimer s disease; Parkinson s disease; Amyloid; Amyloid-beta; alfa-Synuclein; method development; organisk kemi; Organic Chemistry;

    Abstract : Parkinson's and Alzheimer's disease are the two most common neurological disorders in humans. Both conditions involve progressive death of neurons in the central nervous system, decline in bodily functions and eventually (and invariably), death. So far, no cure exists and the available treatments can only ease symptoms. READ MORE

  6. 4. Prediction of Alzheimer’s disease in subjects with Mild Cognitive Impairment using biomarkers

    Author : Peder Buchhave; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Mild Cognitive Impairment; Biomarkers; Prediction; Cerebrospinal fluid; Amyloid.;

    Abstract : Background: Alzheimer’s disease (AD) is the most common cause of dementia. In order to have effect of future disease-modifying therapies for AD, the disease must be identified early, before the patients have developed dementia. Many patients with Mild Cognitive Impairment (MCI) have prodromal AD, but other causes for the syndrome are common. READ MORE

  7. 5. Alzheimer's disease and vascular dementia in population-based studies

    Author : Mats Ribbe; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; cerebrospinal fluid; dementia; hypertension; magnetic resonance imaging; older; survival; vascular dementia;

    Abstract : Dementia, a clinical syndrome with several profiles and causes, is characterised by a decline in cognitive functions, including memory, learning, executive function, attention, language, and social ability. The most common forms of dementia are Alzheimer’s disease and vascular dementia. READ MORE