Search for dissertations about: "cell aging"

Showing result 1 - 5 of 160 swedish dissertations containing the words cell aging.

  2. 1. Early Blood Cell Formation "in sickness and health, ´till death do us part"

    Author : Kees-Jan Pronk; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cell; differentiation; regulation; myeloerythropoeisis; myelopoesis; p16INK4A; aging; tumor necrosis factor;

    Abstract : Hematopoietic stem cells (HSC), the ancestors of all blood cells, have the ability to give rise to mature effector cells through a series of developmental steps. This is a tightly regulated, though a highly dynamic process: on the one hand, dysregulation in steady-state could lead to under- or overgrowth of certain blood cell lineages, whereas, on the other hand, demands for certain mature blood cells can change dramatically in cases like bleeding and infections. READ MORE

  4. 2. Molecular Mechanisms in Hematopoietic Stem Cell Aging

    Author : Gudmundur Norddahl; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The blood is composed of many different cell types that through tightly regulated mechanisms are derived from hematopoietic stem cells (HSCs). In addition, HSCs are able to undergo self-renewing divisions whereby new HSCs are produced. READ MORE

  5. 3. Early fate decisions in hematopoietic stem and progenitor cells. Through the lens of genomic and functional assays

    Author : Fatemeh Safi; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; HSCs; singel cell sc ; scRNA-seq; scATAC-seq; CD9; Aging;

    Abstract : Hematopoietic stem cells (HSCs) are rare cells on top of the differentiation hierarchy of hematopoiesis. HSCs are unique in their combined capacity to differentiate into all mature blood lineages and self-renew to maintain the HSC pool. READ MORE

  6. 4. Caulobacter crescentus folding machines at the interface of inheritance, cell division, and energy metabolism

    Author : Kristen Schroeder; Kristina Jonas; Pierre Genevaux; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chaperones; DnaK; chaperonin; GroESL; protein quality control; protein folding; stress response; cellular aging; cell division; bacterial respiration; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Abstract : All living cells must perform essential biological processes while monitoring and responding to environmental cues. Bacteria are accessible experimental systems in which to study the function of conserved central processes. READ MORE

  7. 5. Investigations of Hematopoietic Stem Cells and Their Age-Associated Alterations

    Author : Alexandra Rundberg Nilsson; Avdelningen för molekylär hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic stem cells; Aging; Serial transplantation; Self-renewal; Flow cytometry; Gene expression;

    Abstract : The hematopoietic stem cell (HSC) has and continues to be extensively investigated, and represents by far the most studied somatic stem cell. Development of various experimental technologies, including fluorescence activated cell sorting (FACS), have been crucial for research advancements within the hematopoietic field. READ MORE