Search for dissertations about: "cell communication physiology"

Showing result 11 - 15 of 16 swedish dissertations containing the words cell communication physiology.

  2. 11. Microbial regulation of PPARgamma : nuclear receptor networks important for colonic homeostasis

    Author : Linda Aronsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : One of the central issues surrounding the physiology of good health is to uncover and understand the molecular networks responsible for its maintenance. The alimentary tract in particular, demands a properly sustained homeostatic control since it is constantly challenged by potentially harmful agents along with innocuous nutrients, with the burden of basic metabolic functions in its ward. READ MORE

  4. 12. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

    Author : Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

    Abstract : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. READ MORE

  5. 13. Molecular simulations of G protein-coupled receptors : A journey into structure-based ligand design and receptor function

    Author : Pierre Matricon; Jens Carlsson; Bjørn Olav Brandsdal; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; G Protein-Coupled Receptor; Molecular Dynamics Simulations; Free Energy Perturbation; Ligand Binding; Fragment-Based Lead Discovery; Molecular Docking Screens; Homology Modeling; GPCR Activation Mechanism; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : The superfamily of G protein-coupled receptors (GPCRs) contains a large number of important drug targets. These cell surface receptors recognize extracellular signaling molecules, which stimulates intracellular pathways that play major roles in human physiology. READ MORE

  6. 14. Engineered extracellular vesicles for biomedical applications

    Author : Dhanu Gupta; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nature's very own nanoparticle, Extracellular vesicles (EVs), are lipid membrane-enclosed vesicles encapsulated with diverse biomolecules and are actively secreted by all cell types for intercellular communication. The unique properties of EVs, such as stability in circulation, biocompatibility, immune tolerance, and the ability to cross biological barriers, render EVs a next-generation drug delivery tool. READ MORE

  7. 15. Gut microbes and the developing brain

    Author : Tim Arentsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The discovery that commensal gut microbiota can influence host development and physiology beyond the gastrointestinal (GI) tract has triggered a paradigm shift in our conceptualization of the origin of human diseases. A growing body of preclinical research has demonstrated that gut microbiota exert a modulatory role on the development and function of brain circuits involved in motor control, emotion and cognition. READ MORE