Search for dissertations about: "cell cycle checkpoints"

Showing result 1 - 5 of 17 swedish dissertations containing the words cell cycle checkpoints.

  2. 1. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  4. 2. Single cell analysis of checkpoints in G1

    Author : Hanna-Stina Martinsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell cycle; restriction point; cyclin D; pRb; rRNA synthesis; cell growth; attachment;

    Abstract : It is becoming evident that defective cell cycle regulation is an important property of the cancer cell. The restriction point (R), a G1 checkpoint after which cell cycle progression becomes independent of extracellular growth factors, is often aberrant in cancer cells. READ MORE

  5. 3. Bioactive Food Compounds with Cancer Preventing Effects in the Colon Focus on Ferulic Acid, para-Coumaric Acid and Lactoferricin

    Author : Birgit Janicke; Livsmedelsteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Caco-2; Gene expression; Cell proliferation; Cell cycle; Bioactive food compounds; Colon cancer; Ferulic acid; para-Coumaric acid; Lactoferricin;

    Abstract : Colorectal cancers are globally ranked as the third most common cancer form in terms of incidence and mortality. Diet has long been considered as one of the main factors affecting population outcome regarding development of cancer in the colon. READ MORE

  6. 4. Mammalian cell cycle regulation : characterisation of three genes expressed in proliferating cells

    Author : Maria Starborg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cell cycle; DNA replication; licensing factor; mitosis; ceheckpoint regulator; centromere regions; cell proliferation marker; nucleolar protein; spermatogenesis;

    Abstract : Proliferating cells undergo different phases in their life cycle. During interphase the cells grow and duplicate their DNA content, followed by a cell division phase, mitosis, which results in two daughter cells. READ MORE

  7. 5. Role of Tripeptidyl peptidase II in cell cycle regulation and tumor progression

    Author : Vaia Stavropoulou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Apoptosis; Burkitt s lymphoma; cell cycle; centrosome; genetic instability; Golgi; mitosis; tripeptidyl-peptidase II;

    Abstract : Protein degradation is essential for many cellular functions and the ubiquitin-proteasome system controls the turnover of most cellular proteins and plays a pivotal role in the regulation of basic physiological processes and in the pathogenesis of many diseases. Alterations in the metabolism of proteins involved in the regulation of cell cycle and apoptosis may result in uncontrolled cell division, which em lead to malignant transformation and tumor development One melt example is the Burkitt's lymphoma (BL), a highly malignant B-cell tumor characterized by chromosomal translocations that constitutively activate the c-myc oncogene. READ MORE