Search for dissertations about: "cell lineage tree"

Showing result 1 - 5 of 6 swedish dissertations containing the words cell lineage tree.

2. 1. The Road to Maturity - Lineage Commitment in early Hematopoiesis

   Author : Charlotta Böiers; Stamcellscentrum (SCC); []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The road to maturity – how do hematopoietic stem cells (HSC) differentiate into mature blood cells? The pathways of lineage commitment during normal hematopoiesis are of great significance in order to understand the underlying events that lead to leukemia, and to the design of proper treatments for prevention and remission of the disease. The route of hematopoiesis can be thought of as a hierarchical tree, with the rare HSCs at the top, transitioning down along the pathways as different progenitors. READ MORE

4. 2. Variational methods for phylogeny and single-cell genomics

   Author : Hazal Koptagel; Jens Lagergren; Alexandre Bouchard-Côté; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Variational inference; single-cell DNA sequencing; cell lineage tree; Bayesian phylogenetic tree inference; Variationsinferens; encellig DNA-sekvensering; cellhärkomstträd; Bayesiansk fylogenetisk trädinferens; Varyasyonel çıkarım; tek hücre DNA dizilimi; hücre soy ağacı; Bayesçi filogenetik ağaç çıkarımı; Datalogi; Computer Science;

   Abstract : The investigation of the evolutionary history of organisms, both at the cellular level and at the species level, is a relevant research topic in computational biology. These investigations lead to a deeper understanding of developmental history, cancer progression, the genetic similarity of species, and more. READ MORE

5. 3. Evolutionary transitions across the tree of life : Phylogenomic case studies in environmental archaea, bacteria and eukaryotes

   Author : Max Emil Schön; Thijs J. G. Ettema; Fabien Burki; David Moreira; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Evolutionary transitions; environmental sequencing; metagenomics; single-cell genomics; phylogenomics; haloarchaea; Hikarchaeia; Rickettsiales; Picozoa; plastid evolution; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Abstract : Microbes form the majority of life on Earth, but have been systematically underrepresented in historical research. The sequencing revolutions of the last two decades have completely changed the way we can study microbial genomic information, giving us the means to probe ever deeper into their evolution. READ MORE

6. 4. Exploration of microbial diversity and evolution through cultivation independent phylogenomics

   Author : Joran Martijn; Thijs J.G. Ettema; Andrew Roger; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cultivation independent genomics; metagenomics; single-cell genomics; metagenomic binning; phylogenetics; phylogenomics; phylogenetic artefacts; comparative genomics; gene tree-species tree reconciliation; rRNA amplicon sequencing; Tara Oceans; origin of mitochondria; Alphaproteobacteria; Rickettsiales; Haloarchaea; endosymbiosis; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Abstract : Our understanding of microbial evolution is largely dependent on available genomic data of diverse organisms. Yet, genome-sequencing efforts have mostly ignored the diverse uncultivable majority in favor of cultivable and sociologically relevant organisms. READ MORE

7. 5. Resolving developing neuronal lineages in the ventral midbrain

   Author : Nigel Kee; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this single cell, and how they are related to one another within an expansive family tree. READ MORE