Search for dissertations about: "cell polarity"

Showing result 1 - 5 of 73 swedish dissertations containing the words cell polarity.

2. 1. RhoGTPase Signaling in Cell Polarity and Gene Regulation

   Author : Ann-Sofi Johansson; Pontus Aspenström; Johan Lennartsson; Christer Larsson; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RhoGTPase; Par6; cell polarity; aPKC; epithelial cell; PDGF; gene regulation; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Abstract : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. READ MORE

4. 2. Regulation of cell polarity and invasion by TGF-β and BMP signaling

   Author : Mahsa Shahidi Dadras; Aristidis Moustakas; Petra Knaus; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer; cancer stem cells; invasion; metastasis; polarity; TGF-β signaling.;

   Abstract : Transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signaling pathways are involved in many physiological processes during embryonic and adult life. TGF-β promotes epithelial to mesenchymal transition (EMT). We identified a gene target of TGF-β signaling, encoding the salt-inducible kinase 1 (SIK1). READ MORE

5. 3. Stochastic modelling and analysis of early mouse development

   Author : Sofia Tapani; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; correlation; CUSUM; mouse; non-stationarity; pronucleus; stochastic differential equation; time series; wavelet decomposition; yeast; CUSUM;

   Abstract : The aim of this thesis is to model and describe dynamical events for biological cells using statistical and mathematical tools. The thesis includes five papers that all relate to stochastic modelling of cells. READ MORE

6. 4. Diversification of TGF-β Signaling in Homeostasis and Disease

   Author : Michael Vanlandewijck; Aristidis Moustakas; Carl-Henrik Heldin; Steven Dooley; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; signaling; SIK; EMT; polarity; Notch; ALK5; p21; growth arrest; Smurf; Smad7; receptor; SNF1LK; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

   Abstract : With the dawn of metazoans, the ability of cells to communicate with each other became of paramount importance in maintaining tissue homeostasis. The transforming growth factor β (TGF-β) signaling pathway, which plays important roles during embryogenesis and in the adult organism, signals via a heterodimeric receptor complex consisting of two type II and two type I receptors. READ MORE

7. 5. Characterization of New Players in Planar Polarity Establishment in Arabidopsis

   Author : Stefano Pietra; Markus Grebe; Niko Geldner; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; SABRE; planar polarity; CLASP; cell division orientation; microtubule cytoskeleton; actin; AIP1; patterning; Developmental Biology; miljömedicinsk utvecklingsbiologi;

   Abstract : Coordinated polarity and differentiation of cells in the plane of a tissue layer are essential to the development of multicellular organisms. Arabidopsis thaliana root hairs and trichomes provide model systems to study the pathways that control planar polarity and cell fate specification in plants. READ MORE