Search for dissertations about: "cell proliferation marker"

Showing result 1 - 5 of 185 swedish dissertations containing the words cell proliferation marker.

  2. 1. TGF-beta signaling in cancer

    Author : Erik Johansson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

    Abstract : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. READ MORE

  4. 2. The Role of Microvascular Pericytes in the Generation of Pro-fibrotic Connective Tissue Cells : Investigations in vitro and in Reactive Tissues in vivo

    Author : Jakob Karén; Christian Sundberg; Gunilla Westergren-Thorsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pericyte fibroblast differentiation fibrosis; Biochemistry; Biokemi; Microbiology; Mikrobiologi; Cell biology; Cellbiologi; Medical Biochemistry; Medicinsk biokemi; Cellforskning; Cell Research; Mikrobiologi; Microbiology;

    Abstract : Pericytes are cells of mesenchymal origin located on the abluminal side, juxtapositioned to the endothelial cells in capillaries, venules and small arterioles. They are important for maintaining vessel integrity in resting tissues as well as the formation and stabilization of new vessels. READ MORE

  5. 3. Hormonal Regulation of Neural Stem Cell Proliferation and Fate Determination

    Author : Karin Brännvall; Dan Lindholm; Sandra Ceccatelli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Neural stem cell; Proliferation; Fate determination; Hormones; Anabolic androgenic steroids; Neurovetenskap; Neurology; Neurologi;

    Abstract : Stem cells have the capacity for both self renewal, and to form all cell types in the body. Interestingly, so called neural stem cells (NSCs) are found in the adult human brain, which is of significance both out of a developmental perspective and from a clinical point of view. READ MORE

  6. 4. Neuropilin-1 regulation of tumor vascularization and growth

    Author : Eric Morin; Lena Claesson-Welsh; Hellmut Augustin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Neuropilin-1; VEGFR2; tumor biology; pancreatic ductal adenocarcinoma; renal cell carcinoma; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. READ MORE

  7. 5. Stem and progenitor cell involvement in acute lymphoblastic leukemia

    Author : Anders Castor; Stamcellscentrum (SCC); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; Haematology; Cytology; oncology; cancerology; Cytologi; onkologi; Medicin människa och djur ; Medicine human and vertebrates ; ETV6-RUNX1; BCR-ABL1; stem cells; Acute lymphoblastic leukemia; extracellular fluids; Hematologi; extracellulära vätskor;

    Abstract : Leukemic stem cells (LSCs) share the capacity of self renewal and extensive proliferation with normal hematopoietic stem cells (HSCs), and are therefore obvious targets for therapy. As such, they need to be identified and characterized in order to elucidate what drives them, and what separates them from their normal counterparts. READ MORE