Search for dissertations about: "cell proliferation parameters"

Showing result 1 - 5 of 60 swedish dissertations containing the words cell proliferation parameters.

  1. 1. Molecular and Cellular Complexity of Glioma Highlights on the Double-Edged-Sword of Infiltration Versus Proliferation and the Involvement of T Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Demet Çağlayan; Uppsala universitet.; [2012]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; Sox2; Sox21; Snail; Bone morphogenetic protein; Sleeping Beauty; Gliomatosis Cerebri; T lymphocytes; T regulatory lymphocytes; Oncology; Onkologi; Biology; Biologi;

    Abstract : Glioblastoma multiforme (GBM), the most common and malignant brain tumor, is characterized by high molecular and cellular heterogeneity within and among tumors. Parameters such as invasive growth, infiltration of immune cells and endothelial proliferation contribute in a systemic manner to maintain the malignancy. READ MORE

  2. 2. Neuropilin-1 regulation of tumor vascularization and growth

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Eric Morin; Uppsala universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; Neuropilin-1; VEGFR2; tumor biology; pancreatic ductal adenocarcinoma; renal cell carcinoma; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Angiogenesis, the formation of new blood vessels from existing ones, is dysregulated during tumor progression as a result of chronic hypoxia and inflammation. Such alterations lead to a lack of vessel hierarchy, and the formation of poorly perfused, leaky and blunt-ended vessels, contributing to disease progression. READ MORE

  3. 3. Influence of neuromodulators and mechanical loading on pathological cell and tissue characteristics in tendinosis

    University dissertation from Umeå : Umeå universitet

    Author : Gloria Fong; Umeå universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; substance P; acetylcholine; transforming growth factor; neuromodulators; mechanical loading; tendinosis; anatomi; Human Anatomy;

    Abstract : Background: Tendinosis is a painful chronic, degenerative condition characterized by objective changes in the tissue structure of a tendon. Hallmark features in tendinosis tendons include increased number of cells (hypercellularity), extracellular matrix (ECM) degradation and disorganized collagen. READ MORE

  4. 4. Improvements of the Bromodeoxyuridine-DNA Flow Cytometry Method for the Study of Cell Proliferation

    University dissertation from The Jubileum Institute, Department of Oncology, Lund University Hospital, S-221 85 LUND, Sweden

    Author : Maria C Johansson; Lund University.; Lunds universitet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; head and neck cancer; [3H]thymidine; energy transfer; cell cycle; xenografted tumours; cultured cells; potential doubling time; labelling index; DNA synthesis time; cell proliferation; growth kinetics; Bromodeoxyuridine; DNA flow cytometry; cancer; onkologi; Cytologi; cancerology; oncology; Cytology;

    Abstract : Potential doubling time (Tpot), DNA synthesis time (TS), and labelling index (LI) are fundamental growth kinetics parameters in clinical and experimental cancer research, which may be of further practical importance regarding prognosis and treatment prediction of cancer. They can be measured by bromodeoxyuridine(BrdUrd)/flow cytometry (FCM) methods, where BrdUrd, an analogue of thymidine, is incorporated into DNA and quantified simultaneously with the DNA content. READ MORE

  5. 5. PREDICTIVE AND PROGNOSTIC MARKERS IN SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

    University dissertation from Lund University

    Author : Eva Henriksson; Lund University.; Lunds universitet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CCND1; cyclin D1; head and neck cancer; cisplatin; TP53; cell proliferation parameters; squamous cell carcinoma; predictive marker;

    Abstract : Survival of patients with locally advanced head and neck squamous cell cancer(HNSCC)is poor, with an overall survival < 50%, despite diagnostic and therapeutic advances. The identification of prognostic and predictive markers could help optimizing treatment. READ MORE