Search for dissertations about: "cell proliferation parameters"

Showing result 16 - 20 of 67 swedish dissertations containing the words cell proliferation parameters.

  2. 16. Strategies to optimize T cell-based cancer immunotherapy

    Author : Simona Vertuani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MHC class 1; CTL; DNA vaccine; HER-2; Retinoic acid;

    Abstract : Remarkable progress has been made in the field of tumor immunology in the past decade but active immunotherapy is not yet an established treatment modality. Tumor associated antigens (TAAs) presented in the form of peptides in association with MHC class 1 can be recognized by T cells and represent major targets of immunotherapy strategies to treat cancer patients. READ MORE

  4. 17. Cell interactions in the CNS and their consequences for neuronal apoptosis

    Author : Mikaela Berglund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Aggregate cultures; apoptosis; automated image analysis; cytochrome c; interactions; JNK; microglia; neuron; neural precursor cells; rotenone; UV.;

    Abstract : The central nervous system consists of an intricate network of neurons and glial cells that depend on reciprocal communication to develop and maintain the vital functions of the brain. if the balance is disturbed by injury or disease, two cell types in particular, microglia and astrocytes, respond by producing factors that help combat the infection or delimit the affected area. READ MORE

  5. 18. Indicators of apoptosis and proliferation in haematological malignancies : with special reference to drug resistance and prognosis

    Author : Barbara MacNamara; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Acute Myeloid Leukaemia; Non-Hodgkin s Lymphoma Drug Resistance; Predictive Factor; International Prognostic Index; Apoptosis; Proliferation; Telomerase; BCL-2; BAX; p53;

    Abstract : Successful treatment of acute myeloid leukaemia (AML) and high-grade non-Hodgkin's lymphoma (HG- NHL) is hampered by development of drug resistance. A better understanding of mechanisms responsible for drug resistance and the identification of factors that predict response to therapy is essential to improve treatment. READ MORE

  6. 19. Regulation of hematopoiesis by the Smad signaling pathway

    Author : Ulrika Blank Savukinas; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; retroviral mediated gene expression; conditional knockout; hematopoietic stem cell; hematopoiesis; Transforming growth factor-beta; Smad signaling; Medicin människa och djur ;

    Abstract : Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and are ultimately responsible for the continuous production of blood cells throughout life. The regulation of HSCs in vivo is tightly regulated by both intrinsic and extrinsic factors. READ MORE

  7. 20. Diversity and focus of CMV specific T-cell responses in patients post-HSCT and with solid tumor

    Author : Thomas Poiret; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human Cytomegalovirus (CMV) is a beta-herpesvirus that commonly infects humans. Most symptoms in healthy individuals are very mild. The virus is never eliminated and remains in the individual life-long. Thus, CMV and the immune response stay in coexistence until the protective response remains. READ MORE