Search for dissertations about: "cell spreading"
Showing result 1 - 5 of 127 swedish dissertations containing the words cell spreading.
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1. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS
Abstract : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. READ MORE
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2. Cell motility : the dynamics of the cortical weave of microfilaments and its relation to microtubules and coated vesicles in fibroblasts and glial cells
Abstract : Actin and myosin, the major components of the microfilament system are found in most - if not all - eukaryotic cells. In muscle they form the basis of the contractile apparatus which generates the rapid, strong and unidirectional movements that characterizes muscle activity. READ MORE
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3. Cell motility : the organization of the microfilament system in cultured cells with special emphasis on the cortical weave of actin filaments
Abstract : The microfilament system formed by actin, myosin and associated proteins constitutes the molecular basis for many of the motile phenomena which eukaryotic cells express. The organization of this system varies considerably from cell type to cell type, and is characterized on one hand by strictly ordered, more or less flexible arrangements of actin filaments and on the other by actin present in primarily a nonfilamentous form ready to polymerize in response to certain stimuli. READ MORE
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4. Roles of the Shb and Cbl Proteins in Signal Transduction and Blood Vessel Formation
Abstract : Formation of blood vessels occurs through two processes: vasculogenesis and angiogenesis, which are regulated by various growth factors such as vascular endothelial growth factor, fibroblast growth factor and platelet-derived growth factor. The present study was carried out in order to investigate the roles of the Shb and Cbl proteins in growth factor-mediated signal transduction and blood vessel formation. READ MORE
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5. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor
Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE
