Search for dissertations about: "cell-based assay"

Showing result 1 - 5 of 30 swedish dissertations containing the words cell-based assay.

  1. 1. Rift Valley fever consequences of virus-host interactions

    University dissertation from Umeå : Umeå universitet

    Author : Maria Baudin; Umeå universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever; Rift Valley fever virus; viral haemorrhagic fever; miscarriage; entry; charge; carbohydrates; high-throughput screening; antiviral; cell-based assay; medicinsk virologi; Medical Virology;

    Abstract : Rift Valley fever virus (RVFV) is a mosquito-borne virus which has the ability to infect a large variety of animals including humans in Africa and Arabian Peninsula. The abortion rate among these animals are close to 100%, and young animals develop severe disease which often are lethal. READ MORE

  2. 2. Deciphering Binding Patterns of Therapeutic Antibodies with Immune Cells From Method Development to Application

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sina Bondza; Jos Buijs; Marika Nestor; Mark Cragg; [2020]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity; binding kinetics; CD20; cell-based assay; immunology; receptor-ligand interaction; therapeutic antibody; Immunologi; Immunology; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Reversible binding, for example between signaling molecules and receptors on the cell surface, is one of the main means to communicate information in cellular systems. Knowledge about how molecules interact is crucial for both understanding biological function and for therapeutic intervention. READ MORE

  3. 3. Monitoring of Cellular Dynamics with Focus on Electrochemical Detection Techniques

    University dissertation from Analytical Chemistry, Lund University

    Author : Arto Heiskanen; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Microfluidic system; Microchip; PC12; Saccharomyces cerevisiae; Electrochemical impedance spectroscopy; Cell adhesion; Amperometry; Exocytosis; Redox environment; Cell-based assay;

    Abstract : This thesis presents work in two main areas of focus, the development of electroanalytical techniques to monitor the dynamics of cellular processes as well as design and fabrication of microelectrode chips for electrochemical detection as well as a prototype microfluidic system to be used for cell analysis and culturing. The electrochemically monitored cellular parameters were the cellular redox environment (CRE), cell adhesion and exocytosis. READ MORE

  4. 4. Rapid sample preparation and bioanalytical techniques for efficient screening of organic pollutants in the environment

    University dissertation from Umeå : Kemi

    Author : Malin Nording; Umeå universitet.; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; accelerated solvent extraction; CAFLUX; food; immunoassay; PAH; PCDD; PCDF; pressurized liquid extraction; soil; CALUX; cell-based bioassay; chemically activated fluorescent gene expression; chemically activated luciferase gene expression; dioxin; ELISA; enzyme-linked immunosorbent assay; feed; NATURAL SCIENCES Chemistry Environmental chemistry; NATURVETENSKAP Kemi Miljökemi;

    Abstract : Large numbers of samples often need to be prepared and analysed in surveys of organic pollutants in the environment, but while the methods commonly used in such surveys can provide abundant detail they are generally costly, time-consuming and require large amounts of resources, so there is a need for simpler techniques. The work underlying this thesis assessed the potential utility of more convenient sample preparation and bioanalytical techniques for rapidly screening various environmental matrices that could be useful complements to higher resolution methods. READ MORE

  5. 5. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

    University dissertation from Umeå : Umeå universitet

    Author : Koushikul Islam; Umeå universitet.; Umeå universitet.; [2018]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

    Abstract : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. READ MORE