Search for dissertations about: "cell-based assay"

Showing result 11 - 15 of 40 swedish dissertations containing the words cell-based assay.

  2. 11. High Content Analysis of Proteins and Protein Interactions by Proximity Ligation

    Author : Karl-Johan Leuchowius; Ola Söderberg; Ulf Landegren; Paul Goldsmith; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation; flow cytometry; high content screening; rolling circle amplification; in situ PLA; single-cell; single-molecule; protein interactions; drug screening; post-translational modifications; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

    Abstract : Fundamental to all biological processes is the interplay between biomolecules such as proteins and nucleic acids. Studies of interactions should therefore be more informative than mere detection of expressed proteins. Preferably, such studies should be performed in material that is as biologically and clinically relevant as possible, i.e. READ MORE

  4. 12. Preclinical tumor-immune modeling : For the identification of immunomodulatory drugs

    Author : Tove Selvin; Mårten Fryknäs; Rolf Larsson; Claes Andersson; Malin Jarvius; Brinton Seashore-Ludlow; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; anti-cancer drugs; preclinical modeling; drug screening; repurposing;

    Abstract : For a long time, the field of cancer research was dominated by a tumor cell-centric view. That, however, changed once it became recognized that medical cancer treatment is largely influenced by the combined effect exerted on both cancer and immune cells. READ MORE

  5. 13. Immune responses against Mycobacterium tuberculosis targets associated to latent and active tuberculosis infection

    Author : Nancy Montserrat Alvarez-Corrales; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Tuberculosis is a worldwide problem particularly in developing countries. Different clinical outcomes, such as the asymptomatic phase during infection or the symptomatic stage during active disease leads to activation and expansion of cellular immune responses in order to control the infection. READ MORE

  6. 14. Microwell devices for single-cell analyses

    Author : Sara Lindström; Helene Andersson-Svahn; Mehmet Toner; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; microwell; miniaturization; microfluidics; cell culture; single-cell; clone; imaging; stem cell; cancer; low volume; high-throughput; Molecular biology; Molekylärbiologi;

    Abstract : Powerful tools for detailed cellular studies are emerging, increasing the knowledge ofthe ultimate target of all drugs: the living cell. Today, cells are commonly analyzed inensembles, i.e. thousands of cells per sample, yielding results on the average responseof the cells. READ MORE

  7. 15. Mechanistic Toxicology : Molecular interactions and underlying mechanisms of dendritic cell activation in skin sensitization

    Author : Tim Lindberg; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skin Sensitization; Toxicology; Mechanisms; Dendritic Cells;

    Abstract : Allergic skin diseases caused by low molecular weight chemical compounds are a major health concern among the general population, especially in certain occupational groups. To limit exposure to such compounds, it is important that thorough risk assessments are performed before products reach the consumer market. READ MORE