Search for dissertations about: "cell-matrix"

Showing result 1 - 5 of 31 swedish dissertations containing the word cell-matrix.

  2. 1. Cell-matrix interactions in neural crest development

    Author : Roberto Perris; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  4. 2. Cell-matrix interactions : master regulators of cancer cell fate?

    Author : Sara Göransson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The development and homeostasis of a multicellular organism require fundamental biological processes like cell proliferation, cell differentiation, cell migration, and controlled cell death. The extracellular matrix (ECM) guides many of these functions, via cell-matrix interactions that function as mechanical and biochemical signaling hubs. READ MORE

  5. 3. The mechanism of integrin inactivation and cell signalling induced by c-erbB2, an oncogenic growth factor receptor

    Author : Shahram Hedjazifar; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; c-erbB2; integrin á2â1; cell-matrix; integrin conformation; PKB; ERK; Rho; ILK; Nck-2;

    Abstract : Overexpression of the oncogenic growth factor receptor, c-erbB2, is linked with poor prognosis in breast carcinomas and is used as a target for therapeutic strategies. To elucidate the mechanism underlying the tumorigenic action of an elevated c-erbB2 level, leading to homodimerization and activation, we have used an inducible system where a hybrid receptor consisting of the cytoplasmic and transmembrane domains of c-erbB2 fused to the extracellular domain of the trkA NGF receptor has been stably transfected into an immortalized mammary epithelial cell line. READ MORE

  6. 4. Nerve gap repair by the use of artificial conduits and cultured cells

    Author : Daniel Kalbermatten; Mikael Wiberg; Ulrich Mennen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose stem cells; cell matrix; fibrin; nerve conduit; nerve gap; Surgery; Kirurgi; kirurgi; Surgery;

    Abstract : Peripheral nerve injuries are often associated with loss of nerve tissue and require autologous nerve grafts to provide a physical substrate for axonal growth. This thesis investigates the use of fibrin as both a tubular conduit to guide nerve regeneration and also as a matrix material to suspend various regenerative cell types within/on poly-3-hydroxybutyrate (PHB) nerve conduits. READ MORE

  7. 5. Cell-matrix interactions in neuronal regeneration : focus on integrins and laminins

    Author : Stefan Plantman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The central and peripheral nervous system (CNS and PNS, respectively) differ in their ability to regenerate after injury. This difference has been attributed both to intrinsic differences in the properties of the neurons and to the extracellular environment. READ MORE