Search for dissertations about: "cellular aging"

Showing result 6 - 10 of 67 swedish dissertations containing the words cellular aging.

  2. 6. Cellular remodeling in response to nutrient exhaustion : From membrane contact sites to autophagy

    Author : Mahsa Ebrahimi; Sabrina Büttner; Cristina Mazzoni; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Aging and longevity; yeast; phosphate restriction; interorganellar communication; autophagy; MVB pathway; NVJs; lipid droplets; nutritional regimes; molekylär biovetenskap; Molecular Bioscience;

    Abstract : Adaptation to fluctuating environments is critical for cellular fitness and survival. Cells need to sense changes in their surroundings and quickly adjust cellular homeostasis and metabolism accordingly. READ MORE

  4. 7. The effect of Plasmodium infection on cellular aging in humans

    Author : Aurelie Miglar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Telomeres play an essential role in maintaining chromosomal integrity and stability. Telomere shortening is part of the natural aging process, nevertheless, accelerated telomere shortening has been linked to chronic diseases and premature aging. READ MORE

  5. 8. Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins

    Author : Rebecca Josefson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; aging; proteostasis; protein quality control; asymmetric inheritance; vesicle trafficking;

    Abstract : Aging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. READ MORE

  6. 9. Functional analysis of the proteasome in eukaryotic organisms

    Author : Marianthi Sakellari; Efstathios S. Gonos; Allan Sirsjö; Richard G. A. Faragher; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteasome; Proteasome activation; Protein synthesis inhibition; Hsp70; Hsp90; Proteostasis; Aging; Alzheimer’s disease; Caenorhabditis elegans; Lifespan extension; SKN-1;

    Abstract : Proteasome degradation machinery is responsible for the turnover of a huge variety of normal and abnormal proteins, thus regulating a plethora of cellular processes. Aging is an inevitable biological process that is characterized by reduced proteasome function that leads to proteotoxic stress. READ MORE

  7. 10. Mechanisms of lipofuscin/ceroid accumulation and its impact on the function of the lysosomal system

    Author : Alexei Terman; Thomas von Zglinicki; Linköpings universitet; []
    Keywords : Aging; Autophagocytosis; Centrophenoxine; Ceroid; Lipofuscin; Lysosomes; Oxidative stress; MEDICINE; MEDICIN;

    Abstract : The accumulation of lipofuscin - an electron-dense, autofluorescent, polymeric, intralysosomal substance - is a recognized hallmark of aging postmitotic cells. Ceroid- a substance very close, or perhaps even identical, to lipofuscin - is a characteristic of various pathological processes, such as lysosomal storage diseases, malnutrition, atherosclerosis, oxidative stress, ionizing radiation, etc. READ MORE