Search for dissertations about: "cellular immortalization"

Showing result 1 - 5 of 15 swedish dissertations containing the words cellular immortalization.

  2. 1. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity

    Author : Sofie Degerman; Göran Roos; John Sedivy; Umeå universitet; []
    Keywords : immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; Pathology; patologi;

    Abstract : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. READ MORE

  4. 2. The Epstein-Barr nuclear antigens 1 & 5; Study of virus-host cellular protein interactions

    Author : Alma Forsman; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; EBNA1; EBNA5; EBNA-LP; cellular network; virus-host protein interactions;

    Abstract : The Epstein-Barr virus (EBV) is the causative agent or cofactor in the aetiology of several human malignancies such as Burkitt’s lymphoma, Hodgkin’s disease, nasopharyngeal carcinoma (NPC) and lymphoproliferative disorder in immunocompromised patients. EBV is a lymphotropic γ-herpes virus infecting more than 90 percent of the population worldwide. READ MORE

  5. 3. Studies on early cellular responses during Epstein-Barr virus infection

    Author : Xinsong Chen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The human gamma-herpesvirus Epstein-Barr virus (EBV) has been implicated in the pathogenesis of a broad spectrum of lymphoid and epithelial cell malignancies. A characteristic property of the virus is the capacity to establish a non-productive growthpromoting infection in B-lymphocytes. READ MORE

  6. 4. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors

    Author : Jonas Fuxe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. READ MORE

  7. 5. MYC and MNT in transcriptional regulation and chromatin dynamics

    Author : Therese Wahlström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The MYC proto-oncogene regulates several cellular processes including cell cycle progression, proliferation, apoptosis and differentiation. In normal cells, MYC expression is induced upon cell cycle entry and is thereafter expressed at low levels during proliferation. READ MORE