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Showing result 1 - 5 of 540 swedish dissertations matching the above criteria.

  2. 1. Cellular regulation of heparan sulfate structure and function

    Author : Fariba Safaiyan; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Heparan sulfate; structure; biosynthesis; sulfation; Biokemi; Biochemistry; Biokemi; Medical and Physiological Chemistry; medicinsk och fysiologisk kemi;

    Abstract : Heparan sulfate (HS) is a sulfated glycosaminoglycan found on cell surfaces and in the extracellular matrix as HS proteoglycans. HS is synthesized as a polymer of alternating glucuronic acid and N-acetylglucosamine units. READ MORE

  4. 2. Structure-function relationships of hormone-sensitive lipase

    Author : Torben Österlund; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; mutagenesis; domain; fold; catalytic triad; lipase; structure; enzymology; Proteiner; enzymologi;

    Abstract : The primary role of hormone-sensitive lipase (HSL), an 84 kDa enzyme of 768 amino acids (in the rat protein), is to hydrolyse stored triacylglycerols in adipocytes of white adipose tissue. Catecholamines and insulin regulate lipolysis through cellular signalling. READ MORE

  5. 3. Asymmetric Cellular Microenvironments

    Author : Susanna Rydholm; Hjalmar Brismar; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physics; Fysik;

    Abstract : This thesis presents methods to combine 3D cell culture, microfluidics and gradients on a controlled cellular scale. 3D cultures in biological extracellular matrix gels or synthetic gels bridge the gap between organ-tissue cultures and traditional 2D cultures. READ MORE

  6. 4. Deciphering Carbohydrate Structure : From NMR Chemical Shifts to Conformational Analysis

    Author : Kevin M. Dorst; Göran Widmalm; Martina Delbianco; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NMR chemical shift prediction; Structural elucidation; Conformational studies; NMR spectroscopy; MD simulations; Organic Chemistry; organisk kemi;

    Abstract : Carbohydrates are ubiquitous in nature and exhibit a multitude of roles. Besides nucleic and amino acids, they can be regarded as the third alphabet of life. They are used as energy source to fuel the cells, as structural building blocks and play a key role in cellular recognition processes. READ MORE

  7. 5. Structure, Mechanism, and Regulation of Sodium/Proton Exchangers

    Author : Iven Winkelmann; Drew David; Rajini Rao; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; sodium proton exchange; SLC9; structure; secondary active transport; membrane protein; Biochemistry; biokemi;

    Abstract : Sodium/proton exchangers (NHEs) are secondary active transporters that are ubiquitously found in all kingdoms of life. They facilitate the exchange of protons for sodium ions or other inorganic ions across biological membranes, regulating pH, sodium levels, and osmotic pressure. READ MORE