Search for dissertations about: "cellular uptake"
Showing result 11 - 15 of 256 swedish dissertations containing the words cellular uptake.
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11. Cell-penetrating peptides and oligonucleotides : Design, uptake and therapeutic applications
Abstract : Regulation of biological processes through the use of genetic elements is a central part of biological research and also holds great promise for future therapeutic applications. Oligonucleotides comprise a class of versatile biomolecules capable of modulating gene regulation. READ MORE
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12. Interactions of the Cell-Penetrating Peptide Penetratin with Model Membranes and Live Cells
Abstract : The delivery of large, hydrophilic molecules, such as proteins and oligonucleotides, to the cytoplasm and nucleus of cells is problematic due to their generally low plasma membrane permeability. With the identification of a number of cell-penetrating peptides, capable of mediating non-endocytotic, intracellular delivery of macromolecular cargos, this obstacle now seems surmountable. READ MORE
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13. Liposomes for mucosal vaccine delivery: physicochemical characterization and biological application
Abstract : Liposomes are attractive vaccine carriers due to their potential to act as adjuvants, and to the fact that their composition and characteristics are virtually endlessly customizable. However, the precise physicochemical profile of an ideal carrier liposome for mucosal vaccines is still widely unknown, and how different properties affect key steps in the acquisition of protective immunity remains to be elucidated. READ MORE
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14. Studies of the interaction of penetratin with phospholipid vesicles
Abstract : .... READ MORE
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15. The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation
Abstract : Anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) exert most of their actions by binding to cannabinoid receptors. The effects of the endocannabinoids are short-lived due to rapid cellular accumulation and metabolism, for AEA, primarily by the enzymes fatty acid amide hydrolase (FAAH). READ MORE