Search for dissertations about: "centrosomes"

Showing result 1 - 5 of 12 swedish dissertations containing the word centrosomes.

  2. 1. Genome instability, gene expression and prognosis in breast cancer

    Author : Ulrike Kronenwett; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast adenocarcinoma; genomic instability; SSI; centrosomes;

    Abstract : Aneuploid cancers are regarded as being more malignant than tumors of other ploidy categories, and they are characterized by increased genomic instability. Our investigations resulted in the characterization of an aneuploid subtype of breast carcinoma that proved to be genomically stable. READ MORE

  4. 2. Human papillomavirus infection, genetic instability and invasive properties of cervical lesions

    Author : Barbro Skyldberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Cervical neoplasia; HPV; ISH; PCR; centrosomes; genetic stability; laminin-5;

    Abstract : Cancer of the uterine cervix is one of the most frequent malignancies in women worldwide. Approximately half a million new cases of cervical cancer are diagnosed each year, and about 200 000 women die from the disease. Human papillomavirus (HPV) DNA has been shown to be present in about 90 % of all cervical cancers. READ MORE

  5. 3. Centrosome aberrations and tumor development

    Author : Kaoru Fujioka; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Centrosome; cervical carcinoma; adrenocortical tumor; tetraploidization; p53; griseofulvin; 13-cis-retinoic acid.;

    Abstract : The transformation of a normal cell to a tumor cell is a result of a failure somewhere in a complicated system of coordination, checkpoints and control mechanisms of inhibitors and activators working as triggers and transactivators of genes of importance for cell cycle progression. In the present thesis, the focus is on an important function that controls the segregation of the chromosomes during cell division to the next generation of two daughter cells. READ MORE

  6. 4. Adhesion-dependent mechanisms regulating mitosis

    Author : Deepesh Kumar Gupta; Staffan Johansson; Kaisa Haglund; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cytokinesis; Centrosome; Septin; Abscission; Mitosis; Integrin; Adhesion; Binucleation; Biokemi; Biochemistry;

    Abstract : Integrin-mediated cell adhesion is required for normal cell cycle progression during G1-S transition and for the completion of cytokinesis. Cancer cells have ability to grow anchorage-independently, but the underlying mechanisms and the functional significance for cancer development are unclear. READ MORE

  7. 5. Regulation of CDK dephosphorylation in mitotic entry

    Author : Arne Lindqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cell cycle progression is orchestrated by the activity of a Cyclin dependent kinase (Cdk) in complex with a Cyclin. The key regulator of early mitotic events is the Cyclin B1/Cdk1 complex. In G2, Cyclin B1/Cdk1 is kept inactive by phosphorylation in the active site of Cdk1. READ MORE