Search for dissertations about: "chaperones"

Showing result 6 - 10 of 88 swedish dissertations containing the word chaperones.

  2. 6. Caulobacter crescentus folding machines at the interface of inheritance, cell division, and energy metabolism

    Author : Kristen Schroeder; Kristina Jonas; Pierre Genevaux; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chaperones; DnaK; chaperonin; GroESL; protein quality control; protein folding; stress response; cellular aging; cell division; bacterial respiration; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

    Abstract : All living cells must perform essential biological processes while monitoring and responding to environmental cues. Bacteria are accessible experimental systems in which to study the function of conserved central processes. READ MORE

  4. 7. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Author : Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Abstract : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. READ MORE

  5. 8. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Author : Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Abstract : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. READ MORE

  6. 9. Molecular And Cellular Networks in Critical Illness Associated Muscle Weakness : Skeletal Muscle Proteostasis in the Intensive Care Unit

    Author : Varuna Chaminda Banduseela; Lars Larsson; Gustavo Nader; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chaperones; autophagy; intensive care unit; heat shock proteins; protein synthesis; proteostasis; ER stress; gene expression; sepsis; neuromuscular blockers; corticosteroids; immobilisation; mechanical ventilation; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

    Abstract : Critical illness associated muscle weakness and muscle dysfunction in intensive care unit (ICU) patients lead to severe morbidity and mortality as well as significant adverse effect on quality of life. Immobilization, mechanical ventilation, neuromuscular blocking agents, corticosteroids, and sepsis have been implicated as important risk factors, but the underlying molecular and cellular mechanisms remain unclear. READ MORE

  7. 10. Cellular Responses to Arsenite and Cadmium - Mechanisms of Toxicity and Defense in Saccharomyces cerevisiae

    Author : Therese Jacobson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; arsenic; arsenite; cadmium; glutathione; extracellular defense; protein aggregation; chaperones; proteasome; Saccharomyces cerevisiae;

    Abstract : All biological systems have to cope with a wide range of metals that are present in the environment. Metals can be essential or beneficial for life, inert or non-essential and toxic, often depending on their chemical form and concentration. Most organisms have evolved defense mechanisms in order to deal with toxic metals. READ MORE