Search for dissertations about: "chemokine coreceptor usage"

Showing result 1 - 5 of 6 swedish dissertations containing the words chemokine coreceptor usage.

2. 1. Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage

   Author : Liselotte Antonsson; Drug Target Discovery; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; evolution; pathogenesis; cerebrospinal fluid; Medicine human and vertebrates ; TAK-779; RANTES; CXCR4; CCR5; coreceptor; GPCR; HIV-1;

   Abstract : The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. READ MORE

4. 2. Significance of HIV-1 genetic subtypes

   Author : Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

   Abstract : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). READ MORE

5. 3. HIV-1 infection during pregnancy and in children : significance of HIV-1 variability and the placental barrier

   Author : Charlotte Casper; Karolinska Institutet; Karolinska Institutet; []
   Keywords : biological phenotype; genetic subtype; chemokine receptor; coreceptor; mother- to-child transmission; placenta; disease progression; child; pregnancy;

   Abstract : With the global increase in human immunodeficiency virus 1 (HIV-1) infection in women of childbearing age, there has also been an alarming increase in the number of mother-to-child transmissions of HIV-1. Although antiretroviral therapy and Cesarian section have been demonstrated to significantly decrease the vertical transmission rate of, these interventions are not widely available in the developing world. READ MORE

6. 4. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

   Author : Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

   Abstract : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. READ MORE

7. 5. HIV-1 variability in relation to host defence mechanisms and disease outcome

   Author : Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

   Abstract : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. READ MORE