Search for dissertations about: "childhood ALL and chemotherapy"

Showing result 1 - 5 of 20 swedish dissertations containing the words childhood ALL and chemotherapy.

  2. 1. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

    Author : Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

    Abstract : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. READ MORE

  4. 2. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

    Author : Peter Jönsson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high dose methotrexate; exposure; dosing algorithms; renal function; cerebrospinal fluid; childhood acute lymphoblastic leukaemia; population pharmacokinetics; relapse risk;

    Abstract : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. READ MORE

  5. 3. Childhood malignant disease and consequences for growth hormone secretion, intellectual function and cardiovascular risk

    Author : Katarina Link; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone deficiency; Insulin sensitivity; Cranial radiotherapy; Neuropsychological performance; Endocrinology; secreting systems; diabetology; Acute Lymphoblastic leukemia; diabetologi; sekretion; Endokrinologi;

    Abstract : In childhood onset growth hormone deficiency (GHD) a reduction in cardiac left ventricular mass (LVMi) and impairment of cardiac systolic function, as well as in glomerular filtration rate (GFR) has been shown. In study I, we showed that a low dose of GH treatment for 10 months resulted in increased LVMi and kidney size. READ MORE

  6. 4. A Study of Renal Function in Children with Cancer

    Author : Lars Hjorth; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatrics; Pediatri; nefrologi; Urologi; nephrology; Urology; children; sequelae; pediatric oncology; chemotherapy; renal toxicity; malignancy; hyperfiltration; iohexol clearance; glomerular filtration rate; kidney disease; Glomerular proteinuria; tubular proteinuria;

    Abstract : Evaluation of long-term side effects of treatment is important due to the growing number of childhood cancer survivors. How kidney function is affected over time needs to be clarified. READ MORE

  7. 5. Cardiopulmonary Function in Healthy Individuals and in Patients After Hematopoietic Cell Transplantation

    Author : Margareta Genberg; Andrei Malinovschi; Eva Nylander; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoietic stem cell transplantation; echocardiography; cardiopulmonary execise testing; stress testing; onchology; childhood leukemia; healthy adults; breathing reserve; oxygen uptake; Clinical Physiology; Klinisk fysiologi;

    Abstract : Background: The cardiopulmonary exercise test (CPET) is the gold standard of clinical exercise tests, combining conventional stress testing with measurement of oxygen uptake and carbon dioxide production. In order to interpret CPET findings, adequate reference values are needed. Currently, no Swedish reference values exist. READ MORE