Search for dissertations about: "children parasite"

Showing result 1 - 5 of 49 swedish dissertations containing the words children parasite.

  2. 1. Parasite virulence and disease severity in Plasmodium falciparum malaria

    Author : Ulf Ribacke; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria stands out as one of the most important infectious diseases and one of the world s leading causes of death. Plasmodium falciparum is the parasite responsible for the great majority of severe disease syndromes and mortality, and affects mainly children and pregnant women. Despite intensive research efforts, the understanding of P. READ MORE

  4. 2. Immunity to malaria: importance of exposure and parasite polymorphism

    Author : Klara Sondén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Malaria continues to carry an intolerable burden of disease and mortality, predominantly on children in Sub-Saharan Africa. An efficacious vaccine would be a powerful tool in the combat against malaria. READ MORE

  5. 3. Modelling and Simulation to Improve Antimalarial Therapy

    Author : Jesmin Permala Lohy Das; Mats Karlsson; Martin Bergstrand; Joel Tarning; Mads Krielgaard; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; pharmacodynamics; malaria; artemisinin; weekly dosing; resistant; pregnant populations; intermittent preventive therapy; parasite clearance; day 3 positivity; nomogram; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-related mortality and morbidity during the past decade. Despite the widespread use of ACT, there is still a considerable knowledge gap with regards to safety, efficacy and pharmacokinetic properties of these drugs, particularly in vulnerable populations like children and pregnant women. READ MORE

  6. 4. Novel combination chemotherapy for treatment and control of schistosomiasis among school children

    Author : Rajabu Hussein Mnkugwe; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite reported success in reducing severe disease-associated morbidities in endemic countries, praziquantel (PZQ) alone has failed to control and eliminate schistosomiasis, partly due to its poor efficacy against immature/juvenile worms. Artemisinin derivatives are efficacious against juvenile schistosomes. READ MORE

  7. 5. Treatment of uncomplicated malaria in Guinea-Bissau

    Author : Paul Erik Kofoed; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Chloroquine; sulphadoxine; pyrimethamine; amodiaquine; quinine; artemisinine; malaria; children; Guinea-Bissau; efficacy; effectiveness.;

    Abstract : Treatment of malaria has become increasingly difficult due to high levels of resistance to the cheap and commonly used antimalarials. In Guinea-Bissau, the first line drug is chloroquine (CQ), the second line drug is sulfadoxine-pyrimethamine (S/P), and the third line therapy is quinine (QU). READ MORE