Search for dissertations about: "chimeras"

Showing result 1 - 5 of 28 swedish dissertations containing the word chimeras.

  2. 1. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

    Author : Mujtaba Hassan; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

    Abstract : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. READ MORE

  4. 2. Mechanisms of lymphocyte selection in physiology and autoimmune pathology

    Author : Stina Forsgren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell activation; la antigens; natural antibodies; non obese diabetic NOD ; T cell mediated autoimmunity; allophenic chimeras;

    Abstract : .... READ MORE

  5. 3. Recombinant mucin-immunoglobulin chimeras as xenoreactive anti-pig antibody absorbers

    Author : Jining Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Human allotransplantation is nowadays the generally accepted treatment of choice for several illnesses leading to organ failure. A major problem facing clinical organ transplantation is the lack of human donor organs and tissues. Xenotransplantation from pig to man is considered a plausible solution to this problem. READ MORE

  6. 4. Protein Interactions Involving the Laminin G-type Domains of Vitamin K-dependent Protein S

    Author : Petra Evenäs; Malmö Klinisk kemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; tyrosine phosphorylation.; Sky receptor; SHBG-like region; protein S; G domain; Gas6; Activated protein C; C4b-binding protein; Proteins; enzymology; Proteiner; enzymologi;

    Abstract : The studies described in this thesis focus on the involvement of the two laminin G-type domains of vitamin K-dependent protein S in various biological contexts. The G-type domains are located in the C-terminal sex-hormone-binding globulin (SHBG)-like region. READ MORE

  7. 5. Molecular dissection of established and proposed members of the Op18/Stathmin family of tubulin binding proteins

    Author : Kristoffer Brännström; Martin Gullberg; Fredrik Ivars; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Op18 Stathmin; Sm16; tubulin; microtubule; schistosoma mansoni; Molecular biology; Molekylärbiologi;

    Abstract : My initial aim was a functional analysis of the conserved Op18/stathmin family of microtubule-regulators, which includes the ubiquitous cytosolic Op18 protein and the neural membrane-attached RB3 and SCG10 proteins. The solved X-ray structure has shown that these proteins form a complex with tubulin -heterodimers via two imperfect helical repeats, which result in two head-to-tail aligned heterodimers in a tandem-tubulin complex. READ MORE