Search for dissertations about: "chiral amine"

Showing result 1 - 5 of 30 swedish dissertations containing the words chiral amine.

2. 1. Amine Transaminases in Multi-Step One-Pot Reactions

   Author : Mattias Anderson; Per Berglund; Frank Hollmann; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biocatalysis; enzyme; amine transaminase; ω-transaminase; amination; primary amine; chiral amine; chemoenzymatic; green chemistry; synthesis; cascade; Bioteknologi; Biotechnology;

   Abstract : Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. READ MORE

4. 2. Amine Transaminases in Biocatalytic Amine Synthesis

   Author : Henrik Land; Per Berglund; Helen C. Hailes; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Amine Transaminase; Biocatalysis; Transamination; Reductive Amination; Enzyme; Enzyme Engineering; Equilibrium Displacement; Screening; Enzyme Stability; Bioteknologi; Biotechnology;

   Abstract : The use of enzymes, nature´s own catalysts, both isolated or as whole cells to perform chemical transformations is called biocatalysis. As a complement to classical chemical catalysis, biocatalysis can be an environmentally friendly and more economical option in the production and synthesis of chemicals. READ MORE

5. 3. Amine transaminase: Process development aspects for chiral amine synthesis

   Author : Tim Börner; Bioteknik; []
   Keywords : ;

   Abstract : Many modern drugs contain chiral amine moieties and the need for more efficient processes to synthesize these amines in high optical purity and concentration are greatly demanded by the fine chemical and pharma industry. Amine transaminases (ATA) allow for the direct asymmetric synthesis of optically pure amines from ketone substrates. READ MORE

6. 4. Transaminase Biocatalysis: Applications and Fundamental Studies

   Author : Federica Ruggieri; Per Berglund; Mariarita Bertoldi; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biocatalysis; enzymatic cascade; transaminase; amine; racemization; PLP; enzyme engineering; Chromobacterium violaceum; protein stability; enzyme stability; molecular dynamics; structural biology; enzyme technology; chiral amines; kinetic resolution; Bioteknologi; Biotechnology;

   Abstract : Biocatalysis is the branch of science at the intersection between chemistry and biology and specifcally dedicated to the application of natural evolvable catalysts, i.e. enzymes, in human-designed chemical processes. Among the array of promising biocatalysts, transaminases (EC 2. READ MORE

7. 5. Development of New Chiral Bicyclic Ligands : Applications in Catalytic Asymmetric Transfer Hydrogenation, Epoxidations, and Epoxide Rearrangements

   Author : Arnaud Gayet; Andersson Pher G.; Hilmersson Göran; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; asymmetric catalysis; transfer hydrogenation; epoxide rearrangement; Organocatalysed epoxidation; chiral ligand; allylic alcohol; kinetic resolution; lithium amide; Organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : This thesis describes the synthesis and application of new chiral bicyclic ligands and their application in asymmetric catalysis. The studies involved: [i] The development of novel chiral bicyclic amino sulfur ligands and their use in transfer hydrogenation. READ MORE