Search for dissertations about: "chiral recognition"

Showing result 1 - 5 of 17 swedish dissertations containing the words chiral recognition.

  2. 1. Chiral recognition on cellulases : The active sites of the enzymes are involved

    Author : Hongbin Henriksson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : Two cellobiohydrolases (CBH I and CBH II) and endoglucanase I (EG I) fromTrichoderma reesei, and CBH 58 from Phanerochaete chrysosporium were immobilized onsilica as chiral stationary phases (CSPs) in HPLC for enantioseparation of a group ofpharmaceutical compounds. CBH I and CBH 58 wore excellent chiral selectors for β-adrenergic blocking agents, whereas CBH II displayed good enantioselectivity for someother compounds The CBHs share the common feature that their active sites are located intunnels. READ MORE

  4. 2. Chiral Recognition by Means of Mass Spectrometry

    Author : Oleksii Rebrov; Mats Larsson; Per Johnsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chirality; Mass spectrometry; Chiral recognition; Gas phase; kemisk fysik; Chemical Physics;

    Abstract : This thesis is based on experimental studies of chiral ions in gas-phase. Electrospray ion source platform (Stockholm University) and commercially available Quadrupole Time-of-Flight mass spectrometer have been used in our studies. READ MORE

  5. 3. Interactions of chiral ions and molecules in gas phase : Towards an understanding of chiral recognition mechanism

    Author : Oleksii Rebrov; Mats Larsson; Richard Thomas; Vitali Zhaunerchyk; Anne Zehnacker-Rentien; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; fysik; Physics;

    Abstract : This thesis comprises the research related to interactions of enantiopure amino acids with chiral and achiral molecules in gas phase. The investigation of the mechanism responsible for chiral discrimination is of the special interest in this work. READ MORE

  6. 4. Molecular Recognition Studies Based on Imprinting Technology

    Author : Cong Yu; Tillämpad biokemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; imprinting; molecular recognition; polymer; chiral separation; acrylamide; chromatography; functional monomer; cross-linking; hydrogen bonding; hydrophobic interactions; aqueous media; solvent; antibody; mimics; receptor; artificial enzyme; Bioteknik; Biotechnology; Biokemi; Metabolism; Biochemistry;

    Abstract : In this thesis, I have focused on five main research areas: 1). A new type of imprinted polymer has been developed, namely the amide MIP. The amide functional monomers showed better hydrogen bonding capabilities in polar organic solvents and the resulting polymers exhibited good enantiomeric recognition properties in organic media. READ MORE

  7. 5. Enantioselective Binding of Designed Propranolol Analogues to the Cellobiohydrolase Cel7A

    Author : Alexandra Fagerström; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Strukturkemi; Structure chemistry; enzymologi; Proteiner; enzymology; Proteins; Naturvetenskap; Natural science; capillary electrophoresis; chiral recognition; enantiomeric selectivity; cellobiohydrolase Cel7A; propranolol; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes the affinity and enantiomeric selectivity of the cellobiohydrolase Cel7A (isolated from Hypocrea jercorina). The chiral recognition of the enzyme has been studied with respect to amino alcohols and new ligands have been designed, based on the structure of the common ?-blocker propranolol. READ MORE